Seroatlas · Human Serome Atlas

CLIP3

CAP-Gly domain-containing linker protein 3

Also known as: CLIP3_HUMAN, CLIPR-59, RSNL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DZ5
Gene: CLIP3
Ensembl: ENSG00000105270
Chromosome: 19
Canonical length: 547 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q96DZ5|CLIP3
     1  MTKTDPAPMA PPPRGEEEEE EEEDEPVPEA PSPTQERRQK PVVHPSAPAP LPKDYAFTFF
    61  DPNDPACQEI LFDPQTTIPE LFAIVRQWVP QVQHKIDVIG NEILRRGCHV NDRDGLTDMT
   121  LLHYACKAGA HGVGDPAAAV RLSQQLLALG ADVTLRSRWT NMNALHYAAY FDVPDLVRVL
   181  LKGARPRVVN STCSDFNHGS ALHIAASSLC LGAAKCLLEH GANPALRNRK GQVPAEVVPD
   241  PMDMSLDKAE AALVAKELRT LLEEAVPLSC ALPKVTLPNY DNVPGNLMLS ALGLRLGDRV
   301  LLDGQKTGTL RFCGTTEFAS GQWVGVELDE PEGKNDGSVG GVRYFICPPK QGLFASVSKI
   361  SKAVDAPPSS VTSTPRTPRM DFSRVTGKGR REHKGKKKTP SSPSLGSLQQ RDGAKAEVGD
   421  QVLVAGQKQG IVRFYGKTDF APGYWYGIEL DQPTGKHDGS VFGVRYFTCP PRHGVFAPAS
   481  RIQRIGGSTD SPGDSVGAKK VHQVTMTQPK RTFTTVRTPK DIASENSISR LLFCCWFPWM
   541  LRAEMQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 211 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 211 nTPM
cerebral cortex: 208 nTPM
amygdala: 153 nTPM
hypothalamus: 149 nTPM
hippocampal formation: 136 nTPM
basal ganglia: 134 nTPM

Single-cell type

other brain neurons: 62 nCPM
brain inhibitory neurons: 57 nCPM
brain excitatory neurons: 52 nCPM
retinal amacrine cells: 43 nCPM
oligodendrocyte progenitor cells: 38 nCPM
late spermatids: 38 nCPM

Immune cell

NK-cell: 0.4 nTPM
eosinophil: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

cerebral cortex: 400 nTPM
midbrain: 397 nTPM
pons: 359 nTPM
hypothalamus: 316 nTPM
basal ganglia: 292 nTPM
amygdala: 290 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.68
gnomAD missense Z: 3.47
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLIP3 as an antibody target. Whether an autoantibody or antibody against CLIP3 could matter depends on whether native CLIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLIP3 is annotated at the cell surface, where native CLIP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CLIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...