Seroatlas · Human Serome Atlas

TAF8

Transcription initiation factor TFIID subunit 8

Also known as: FLJ32821, TAF(II)43, TAF8_HUMAN, TBN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7C8
Gene: TAF8
Ensembl: ENSG00000137413
Chromosome: 6
Canonical length: 310 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mid piece

OverviewNCBI Gene

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q7Z7C8|TAF8
     1  MADAAATAGA GGSGTRSGSK QSTNPADNYH LARRRTLQVV VSSLLTEAGF ESAEKASVET
    61  LTEMLQSYIS EIGRSAKSYC EHTARTQPTL SDIVVTLVEM GFNVDTLPAY AKRSQRMVIT
   121  APPVTNQPVT PKALTAGQNR PHPPHIPSHF PEFPDPHTYI KTPTYREPVS DYQVLREKAA
   181  SQRRDVERAL TRFMAKTGET QSLFKDDVST FPLIAARPFT IPYLTALLPS ELEMQQMEET
   241  DSSEQDEQTD TENLALHISM EDSGAEKENT SVLQQNPSLS GSRNGEENII DNPYLRPVKK
   301  PKIRRKKSLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thymus: 23 nTPM
skeletal muscle: 17 nTPM
bone marrow: 17 nTPM
tongue: 17 nTPM
tonsil: 16 nTPM
heart muscle: 16 nTPM

Single-cell type

endometrial luminal cells: 257 nCPM
endometrial secretory cells: 66 nCPM
endometrial glandular cells: 64 nCPM
endometrial ciliated cells: 56 nCPM
adipocytes: 54 nCPM
distal convoluted tubule cells: 44 nCPM

Immune cell

non-classical monocyte: 33 nTPM
eosinophil: 27 nTPM
plasmacytoid DC: 23 nTPM
basophil: 21 nTPM
intermediate monocyte: 17 nTPM
memory B-cell: 17 nTPM

Brain region

choroid plexus: 25 nTPM
medulla oblongata: 22 nTPM
thalamus: 22 nTPM
cerebral cortex: 21 nTPM
basal ganglia: 20 nTPM
white matter: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAF8.

Disease | AllUniProt

Conditions TAF8 is implicated in, by any mechanism.

Neurodevelopmental disorder with severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy (NEDMLHB) MIM:619972

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 95 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with severe motor impairment, absent language, cerebral hypomyelination, and brain atrophy
Neurodevelopmental disorder
Severe global developmental delay
Microcephaly
Partial agenesis of the corpus callosum

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.91
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Bromodomain associated domain
Histone-fold
Bromodomain associated
Transcription factor TFIID, subunit 8, C-terminal
Transcription initiation factor TFIID subunit 8
Transcription factor TFIID complex subunit 8 C-term

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF8 as an antibody target. Whether an autoantibody or antibody against TAF8 could matter depends on whether native TAF8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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