Seroatlas · Human Serome Atlas

APBB1IP

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Also known as: AB1IP_HUMAN, INAG1, RIAM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z5R6
Gene
APBB1IP
Ensembl
ENSG00000077420
Chromosome
10
Canonical length
666 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q7Z5R6|APBB1IP
     1  MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK DLNESLNALE
    61  DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ ASIFSGAASL GYGTNVAATG
   121  ISQYEDDLPP PPADPVLDLP LPPPPPEPLS QEEEEAQAKA DKIKLALEKL KEAKVKKLVV
   181  KVHMNDNSTK SLMVDERQLA RDVLDNLFEK THCDCNVDWC LYEIYPELQI ERFFEDHENV
   241  VEVLSDWTRD TENKILFLEK EEKYAVFKNP QNFYLDNRGK KESKETNEKM NAKNKESLLE
   301  ESFCGTSIIV PELEGALYLK EDGKKSWKRR YFLLRASGIY YVPKGKTKTS RDLACFIQFE
   361  NVNIYYGTQH KMKYKAPTDY CFVLKHPQIQ KESQYIKYLC CDDTRTLNQW VMGIRIAKYG
   421  KTLYDNYQRA VAKAGLASRW TNLGTVNAAA PAQPSTGPKT GTTQPNGQIP QATHSVSAVL
   481  QEAQRHAETS KDKKPALGNH HDPAVPRAPH APKSSLPPPP PVRRSSDTSG SPATPLKAKG
   541  TGGGGLPAPP DDFLPPPPPP PPLDDPELPP PPPDFMEPPP DFVPPPPPSY AGIAGSELPP
   601  PPPPPPAPAP APVPDSARPP PAVAKRPPVP PKRQENPGHP GGAGGGEQDF MSDLMKALQK
   661  KRGNVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APBB1IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
135 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 135 nTPM
  • spleen: 57 nTPM
  • lymph node: 47 nTPM
  • appendix: 45 nTPM
  • bone marrow: 43 nTPM
  • tonsil: 42 nTPM

Single-cell type

  • neutrophils: 2,910 nCPM
  • microglia: 2,215 nCPM
  • neutrophil progenitors: 865 nCPM
  • adipocytes: 600 nCPM
  • monocytes: 440 nCPM
  • kupffer cells: 436 nCPM

Immune cell

  • neutrophil: 183 nTPM
  • basophil: 82 nTPM
  • eosinophil: 59 nTPM
  • plasmacytoid DC: 50 nTPM
  • naive B-cell: 40 nTPM
  • non-classical monocyte: 39 nTPM

Brain region

  • white matter: 60 nTPM
  • medulla oblongata: 39 nTPM
  • spinal cord: 36 nTPM
  • thalamus: 34 nTPM
  • pons: 30 nTPM
  • midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.37
gnomAD pLI
0.85
gnomAD missense Z
1.29
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APBB1IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APBB1IP as an antibody target. Whether an autoantibody or antibody against APBB1IP could matter depends on whether native APBB1IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APBB1IP is annotated at the cell surface, where native APBB1IP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label APBB1IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APBB1IP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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