Seroatlas · Human Serome Atlas

GPM6A

Neuronal membrane glycoprotein M6-a

Also known as: GPM6, GPM6A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51674
Gene: GPM6A
Ensembl: ENSG00000150625
Chromosome: 4
Canonical length: 278 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable calcium channel activity. Involved in neuron migration and stem cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>P51674|GPM6A
     1  MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA LSGTVNILQT
    61  YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM VEGFFTTGAI KDLYGDFKIT
   121  TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF
   181  GIVTIGEEKK ICTVSENFLR MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA
   241  YVKDACRMQK YEDIKSKEEQ ELHDIHSTRS KERLNAYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPM6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 614 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 614 nTPM
cerebellum: 490 nTPM
amygdala: 487 nTPM
hippocampal formation: 315 nTPM
basal ganglia: 311 nTPM
hypothalamus: 183 nTPM

Single-cell type

astrocytes: 5,162 nCPM
bergmann glia: 5,063 nCPM
choroid plexus epithelial cells: 2,309 nCPM
retinal pigment epithelial cells: 2,110 nCPM
oligodendrocyte progenitor cells: 1,866 nCPM
müller glia: 1,699 nCPM

Immune cell

memory B-cell: 35 nTPM
naive B-cell: 17 nTPM
plasmacytoid DC: 2.9 nTPM
total PBMC: 0.7 nTPM
myeloid DC: 0.2 nTPM
basophil: 0 nTPM

Brain region

cerebral cortex: 784 nTPM
cerebellum: 642 nTPM
basal ganglia: 628 nTPM
hippocampal formation: 605 nTPM
amygdala: 516 nTPM
white matter: 461 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 0.99
gnomAD missense Z: 1.96
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPM6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPM6A as an antibody target. Whether an autoantibody or antibody against GPM6A could matter depends on whether native GPM6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPM6A is annotated at the cell surface, where native GPM6A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPM6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...