Seroatlas · Human Serome Atlas

FAM135B

Protein FAM135B

Also known as: C8ORFK32, F135B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q49AJ0
Gene: FAM135B
Ensembl: ENSG00000147724
Chromosome: 8
Canonical length: 1406 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Predicted to be involved in lipid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1406 residues, UniProt reviewed canonical sequence.

>Q49AJ0|FAM135B
     1  MSEIQGTVEF SVELHKFYNV DLFQRGYYQI RVTLKVSSRI PHRLSASIAG QTESSSLHSA
    61  CVHDSTVHSR VFQILYRNEE VPINDAVVFR VHLLLGGERM EDALSEVDFQ LKVDLHFTDS
   121  EQQLRDVAGA PMVSSRTLGL HFHPRNGLHH QVPVMFDYFH LSVISVTVHA ALVALQQPLI
   181  SFTRPGRGSW LGKGGPDTGQ EQSIISLENL VFGAGYCKPT SSEGSFYITS ENCMQHAHKW
   241  HRDLCLLLLH AYRGLRLHFL VIMRDIPELP HTELEALAVE ETLSQLCSEL QMLNNPEKIA
   301  EQISKDLAWL TSHMMTLWTQ FLDTVTLHSQ VTTYLTQEHH TLRVRRFSEA FFYMEHQKLA
   361  VLTFQENLIQ THSQLSLDIR NSEYLTSMPP LPAECLDIDG DWNTLPVIFE DRYVDCPATG
   421  HNLSVYPNFD VPVTSPTIMN LKDKEDNCMV NSNLSFREDL VLSTIKPSQM DSDEEVIRCP
   481  EPGENVATQN HMDMCSESQV YISIGEFQNK AGVPEDECWT GQTSDAGTYP VADVDTSRRS
   541  PGPEDGQAPV LTYIDVKSSN KNPSRAEPLV AFNAQHESRS SRDKYGLDRT GLSKVVVGGS
   601  HQNAISSDKT TLHELSTLGK GIDQEGKMVL LSLKLTPSEP CDPLSSTLRE PLDIRSSLKD
   661  SHTEEQEELS VLSGVIKRSS SIISDSGIES EPSSVAWSEA RSRALELPSD REVLHPFVRR
   721  HALHRNSLEG GHTESNTSLP SGIQASLTSI SSLPFEEDER EVALTKLTKS VSAPHISSPE
   781  EAAEDADTKQ QDGGFAEPSD MHSKSQGSPG SCSQLCGDSG TDAGADHPLV EIVLDADNQQ
   841  GPGYIDIPKG KGKQFDAQGH CLPDGRTENT PGVETKGLNL KIPRVIALEN PRTRSLHRAL
   901  EETPKGMPKD LNVGQQALSN SGISEVEGLS QHQVPELSCT SAADAINRNS TGQQSQSGSP
   961  CIMDDTAFNR GVNAFPEAKH KAGTVCPTVT HSVHSQVLKN QELKAGTSIM GSHLTSAETF
  1021  TLDSLKAVEV VNLSVSCTAT CLPFSSVPKE TPARAGFSSK QTLFPITHQP LGSFGVVSTH
  1081  SSTLDEEVSE RMFSFYQAKE KFKKELKIEG FLYSDLTVLA SDIPYFPPEE EEENLEDGIH
  1141  LVVCVHGLDG NSADLRLVKT FIELGLPGGK LDFLMSEKNQ MDTFADFDTM TDRLLDEIIQ
  1201  HIQLYNLSIS RISFIGHSLG NIIIRSVLTR PRFRYYLNKL HTFLSLSGPH LGTLYNNSTL
  1261  VSTGLWLMQK LKKSGSLLQL TFRDNADLRK CFLYQLSQKT GLQYFKNVVL VASPQDRYVP
  1321  FHSARIEMCK TALKDRHTGP VYAEMINNLL GPLVEAKDCT LIRHNVFHAL PNTANTLIGR
  1381  AAHIAVLDSE LFLEKFFLVA GLNYFK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM135B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

retina: 9.1 nTPM
cerebellum: 6.6 nTPM
cerebral cortex: 4.6 nTPM
testis: 3.6 nTPM
basal ganglia: 2.8 nTPM
adrenal gland: 2.5 nTPM

Single-cell type

retinal bipolar cells: 706 nCPM
cone photoreceptor cells: 605 nCPM
early spermatids: 518 nCPM
thyrotrophs: 270 nCPM
brain inhibitory neurons: 262 nCPM
ependymal cells: 253 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 38 nTPM
hippocampal formation: 30 nTPM
cerebellum: 27 nTPM
white matter: 26 nTPM
basal ganglia: 25 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lipid metabolic process

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of FAM135B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZDHHC17

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM135B as an antibody target. Whether an autoantibody or antibody against FAM135B could matter depends on whether native FAM135B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM135B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM135B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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