Seroatlas · Human Serome Atlas

SLAIN1

SLAIN motif-containing protein 1

Also known as: C13orf32, FLJ30046, SLAI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8ND83
Gene: SLAIN1
Ensembl: ENSG00000139737
Chromosome: 13
Canonical length: 568 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Predicted to be located in microtubule plus-end. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>Q8ND83|SLAIN1
     1  MMAEQVKCAS AGVSSGAGSG PVVNAELEVK KLQELVRKLE KQNEQLRSRA ASAAAAPHLL
    61  LLPPPPPAAP PPAGLQPLGP RSPPAATATA AASGGLGPAF PGTFCLPSPA PSLLCSLAQP
   121  PEAPFVYFKP AAGFFGAGGG GPEPGGAGTP PGAAAAPPSP PPTLLDEVEL LDLESVAAWR
   181  DEDDYTWLYI GSSKTFTSSE KSLTPLQWCR HVLDNPTPEM EAARRSLCFR LEQGYTSRGS
   241  PLSPQSSIDS ELSTSELEDD SISMGYKLQD LTDVQIMARL QEESLRQDYA STSASVSRHS
   301  SSVSLSSGKK GTCSDQEYDQ YSLEDEEEFD HLPPPQPRLP RCSPFQRGIP HSQTFSSIRE
   361  CRRSPSSQYF PSNNYQQQQY YSPQAQTPDQ QPNRTNGDKL RRSMPNLARM PSTTAISSNI
   421  SSPVTVRNSQ SFDSSLHGAG NGISRIQSCI PSPGQLQHRV HSVGHFPVSI RQPLKATAYV
   481  SPTVQGSSNM PLSNGLQLYS NTGIPTPNKA AASGIMGRSA LPRPSLAING SNLPRSKIAQ
   541  PVRSFLQPPK PLSSLSTLRD GNWRDGCY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLAIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 335 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 335 nTPM
midbrain: 153 nTPM
hippocampal formation: 134 nTPM
cerebral cortex: 117 nTPM
basal ganglia: 101 nTPM
amygdala: 90 nTPM

Single-cell type

oligodendrocytes: 1,224 nCPM
oligodendrocyte progenitor cells: 349 nCPM
müller glia: 246 nCPM
sertoli cells: 220 nCPM
brain inhibitory neurons: 119 nCPM
brain excitatory neurons: 113 nCPM

Immune cell

T-reg: 2.3 nTPM
naive CD8 T-cell: 1.7 nTPM
MAIT T-cell: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM
memory CD4 T-cell: 1 nTPM
memory CD8 T-cell: 0.9 nTPM

Brain region

white matter: 805 nTPM
basal ganglia: 601 nTPM
medulla oblongata: 546 nTPM
midbrain: 530 nTPM
pons: 490 nTPM
thalamus: 451 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.9
gnomAD missense Z: 1.22
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytoskeleton

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLAIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLAIN1 as an antibody target. Whether an autoantibody or antibody against SLAIN1 could matter depends on whether native SLAIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLAIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLAIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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