Seroatlas · Human Serome Atlas

SNAP23

Synaptosomal-associated protein 23

Also known as: HsT17016, SNAP23A, SNAP23B, SNP23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00161
Gene
SNAP23
Ensembl
ENSG00000092531
Chromosome
15
Canonical length
211 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Primary cilium
Quaternary structure
Homotetramer

OverviewNCBI Gene

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>O00161|SNAP23
     1  MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE QLNRIEEGLD
    61  QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK TTWGDGGENS PCNVVSKQPG
   121  PVTNGQLQQP TTGAASGGYI KRITNDARED EMEENLTQVG SILGNLKDMA LNIGNEIDAQ
   181  NPQIKRITDK ADTNRDRIDI ANARAKKLID S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNAP23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 79 nTPM
  • tonsil: 74 nTPM
  • spleen: 66 nTPM
  • placenta: 65 nTPM
  • appendix: 59 nTPM
  • blood vessel: 58 nTPM

Single-cell type

  • platelets: 1,140 nCPM
  • megakaryocytes: 501 nCPM
  • late spermatids: 401 nCPM
  • neutrophils: 288 nCPM
  • kupffer cells: 240 nCPM
  • pancreatic duct cells: 229 nCPM

Immune cell

  • eosinophil: 682 nTPM
  • neutrophil: 368 nTPM
  • basophil: 246 nTPM
  • intermediate monocyte: 240 nTPM
  • non-classical monocyte: 239 nTPM
  • total PBMC: 181 nTPM

Brain region

  • cerebral cortex: 78 nTPM
  • white matter: 54 nTPM
  • pons: 44 nTPM
  • choroid plexus: 38 nTPM
  • medulla oblongata: 37 nTPM
  • thalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.92
gnomAD missense Z
0.83
DepMap mean gene effect
-0.72
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNAP23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNAP23 as an antibody target. Whether an autoantibody or antibody against SNAP23 could matter depends on whether native SNAP23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNAP23 is annotated at the cell surface, where native SNAP23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SNAP23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNAP23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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