Seroatlas · Human Serome Atlas

SLC9A9

Sodium/hydrogen exchanger 9

Also known as: FLJ35613, NHE9, SL9A9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVB4
Gene: SLC9A9
Ensembl: ENSG00000181804
Chromosome: 3
Canonical length: 645 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q8IVB4|SLC9A9
     1  MERQSRVMSE KDEYQFQHQG AVELLVFNFL LILTILTIWL FKNHRFRFLH ETGGAMVYGL
    61  IMGLILRYAT APTDIESGTV YDCVKLTFSP STLLVNITDQ VYEYKYKREI SQHNINPHQG
   121  NAILEKMTFD PEIFFNVLLP PIIFHAGYSL KKRHFFQNLG SILTYAFLGT AISCIVIGLI
   181  MYGFVKAMIH AGQLKNGDFH FTDCLFFGSL MSATDPVTVL AIFHELHVDP DLYTLLFGES
   241  VLNDAVAIVL TYSISIYSPK ENPNAFDAAA FFQSVGNFLG IFAGSFAMGS AYAIITALLT
   301  KFTKLCEFPM LETGLFFLLS WSAFLSAEAA GLTGIVAVLF CGVTQAHYTY NNLSSDSKIR
   361  TKQLFEFMNF LAENVIFCYM GLALFTFQNH IFNALFILGA FLAIFVARAC NIYPLSFLLN
   421  LGRKQKIPWN FQHMMMFSGL RGAIAFALAI RNTESQPKQM MFTTTLLLVF FTVWVFGGGT
   481  TPMLTWLQIR VGVDLDENLK EDPSSQHQEA NNLDKNMTKA ESARLFRMWY SFDHKYLKPI
   541  LTHSGPPLTT TLPEWCGPIS RLLTSPQAYG EQLKEDDVEC IVNQDELAIN YQEQASSPCS
   601  PPARLGLDQK ASPQTPGKEN IYEGDLGLGG YELKLEQTLG QSQLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC9A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 19 nTPM
placenta: 15 nTPM
thymus: 14 nTPM
lymph node: 14 nTPM
urinary bladder: 13 nTPM
tonsil: 13 nTPM

Single-cell type

medullary thymic epithelial cells: 1,572 nCPM
microglia: 1,383 nCPM
hofbauer cells: 1,256 nCPM
macrophages: 831 nCPM
kupffer cells: 703 nCPM
corticotrophs: 540 nCPM

Immune cell

intermediate monocyte: 11 nTPM
T-reg: 9.3 nTPM
non-classical monocyte: 9.1 nTPM
myeloid DC: 8.4 nTPM
memory CD8 T-cell: 7.5 nTPM
classical monocyte: 6.2 nTPM

Brain region

medulla oblongata: 41 nTPM
white matter: 36 nTPM
hypothalamus: 32 nTPM
spinal cord: 28 nTPM
basal ganglia: 27 nTPM
thalamus: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC9A9.

Disease | AllUniProt

Conditions SLC9A9 is implicated in, by any mechanism.

Autism 16 (AUTS16) MIM:613410

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 145 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Colorectal cancer
Autism, susceptibility to, 16

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC9A9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC9A9 as an antibody target. Whether an autoantibody or antibody against SLC9A9 could matter depends on whether native SLC9A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC9A9 is annotated at the cell surface, where native SLC9A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC9A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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