Seroatlas · Human Serome Atlas

SPRY4

Protein sprouty homolog 4

Also known as: SPY4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C004
Gene: SPRY4
Ensembl: ENSG00000187678
Chromosome: 5
Canonical length: 299 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9C004|SPRY4
     1  MEPPIPQSAP LTPNSVMVQP LLDSRMSHSR LQHPLTILPI DQVKTSHVEN DYIDNPSLAL
    61  TTGPKRTRGG APELAPTPAR CDQDVTHHWI SFSGRPSSVS SSSSTSSDQR LLDHMAPPPV
   121  ADQASPRAVR IQPKVVHCQP LDLKGPAVPP ELDKHFLLCE ACGKCKCKEC ASPRTLPSCW
   181  VCNQECLCSA QTLVNYGTCM CLVQGIFYHC TNEDDEGSCA DHPCSCSRSN CCARWSFMGA
   241  LSVVLPCLLC YLPATGCVKL AQRGYDRLRR PGCRCKHTNS VICKAASGDA KTSRPDKPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRY4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 29 nTPM
adipose tissue: 26 nTPM
lung: 23 nTPM
heart muscle: 17 nTPM
pituitary gland: 17 nTPM
adrenal gland: 17 nTPM

Single-cell type

oligodendrocyte progenitor cells: 100 nCPM
alveolar cells type 2: 98 nCPM
adrenal medulla cells: 75 nCPM
pituicytes/fscs: 65 nCPM
pericytes: 42 nCPM
adrenal cortex cells: 38 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 23 nTPM
medulla oblongata: 15 nTPM
cerebral cortex: 15 nTPM
hypothalamus: 15 nTPM
pons: 13 nTPM
hippocampal formation: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPRY4.

Disease | AllUniProt

Conditions SPRY4 is implicated in, by any mechanism.

Hypogonadotropic hypogonadism 17 with or without anosmia (HH17) MIM:615266

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 125 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypogonadotropic hypogonadism 17 with or without anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein kinase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPRY4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRY4 as an antibody target. Whether an autoantibody or antibody against SPRY4 could matter depends on whether native SPRY4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRY4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRY4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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