Seroatlas · Human Serome Atlas

GOLPH3L

Golgi phosphoprotein 3-like

Also known as: GLP3L_HUMAN, GPP34R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4A5
Gene: GOLPH3L
Ensembl: ENSG00000143457
Chromosome: 1
Canonical length: 285 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9H4A5|GOLPH3L
     1  MTTLTHRARR TEISKNSEKK MESEEDSNWE KSPDNEDSGD SKDIRLTLME EVLLLGLKDK
    61  EGYTSFWNDC ISSGLRGGIL IELAMRGRIY LEPPTMRKKR LLDRKVLLKS DSPTGDVLLD
   121  ETLKHIKATE PTETVQTWIE LLTGETWNPF KLQYQLRNVR ERIAKNLVEK GILTTEKQNF
   181  LLFDMTTHPV TNTTEKQRLV KKLQDSVLER WVNDPQRMDK RTLALLVLAH SSDVLENVFS
   241  SLTDDKYDVA MNRAKDLVEL DPEVEGTKPS ATEMIWAVLA AFNKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLPH3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

rectum: 34 nTPM
epididymis: 31 nTPM
colon: 29 nTPM
esophagus: 25 nTPM
thyroid gland: 24 nTPM
fallopian tube: 24 nTPM

Single-cell type

esophageal apical cells: 365 nCPM
goblet cells: 157 nCPM
respiratory ciliated cells: 154 nCPM
pancreatic acinar cells: 151 nCPM
colonocytes: 130 nCPM
breast lactating cells: 126 nCPM

Immune cell

NK-cell: 18 nTPM
MAIT T-cell: 13 nTPM
naive CD4 T-cell: 13 nTPM
plasmacytoid DC: 13 nTPM
T-reg: 12 nTPM
memory B-cell: 11 nTPM

Brain region

choroid plexus: 27 nTPM
midbrain: 26 nTPM
pons: 23 nTPM
hypothalamus: 22 nTPM
medulla oblongata: 20 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLPH3L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZDHHC17

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLPH3L as an antibody target. Whether an autoantibody or antibody against GOLPH3L could matter depends on whether native GOLPH3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLPH3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLPH3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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