Seroatlas · Human Serome Atlas

DNAJC5

DnaJ homolog subfamily C member 5

Also known as: CLN4, DNAJC5A, DNJC5_HUMAN, FLJ00118, FLJ13070

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3Z4
Gene
DNAJC5
Ensembl
ENSG00000101152
Chromosome
20
Canonical length
198 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles,Perinuclear theca,Principal piece,End piece
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9H3Z4|DNAJC5
     1  MADQRQRSLS TSGESLYHVL GLDKNATSDD IKKSYRKLAL KYHPDKNPDN PEAADKFKEI
    61  NNAHAILTDA TKRNIYDKYG SLGLYVAEQF GEENVNTYFV LSSWWAKALF VFCGLLTCCY
   121  CCCCLCCCFN CCCGKCKPKA PEGEETEFYV SPEDLEAQLQ SDEREATDTP IVIQPASATE
   181  TTQLTADSHP SYHTDGFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 53 nTPM
  • cerebellum: 52 nTPM
  • basal ganglia: 43 nTPM
  • hypothalamus: 37 nTPM
  • amygdala: 33 nTPM
  • esophagus: 32 nTPM

Single-cell type

  • esophageal apical cells: 321 nCPM
  • late spermatids: 200 nCPM
  • microglia: 107 nCPM
  • neutrophils: 99 nCPM
  • choroid plexus epithelial cells: 94 nCPM
  • neutrophil progenitors: 94 nCPM

Immune cell

  • plasmacytoid DC: 3.9 nTPM
  • intermediate monocyte: 3.7 nTPM
  • classical monocyte: 3.2 nTPM
  • gdT-cell: 3.2 nTPM
  • neutrophil: 3.1 nTPM
  • non-classical monocyte: 3.1 nTPM

Brain region

  • cerebral cortex: 118 nTPM
  • hippocampal formation: 110 nTPM
  • pons: 106 nTPM
  • hypothalamus: 106 nTPM
  • basal ganglia: 104 nTPM
  • amygdala: 98 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DNAJC5.

Disease | AllUniProt

Conditions DNAJC5 is implicated in, by any mechanism.

  • Ceroid lipofuscinosis, neuronal, 4B (Kufs type), autosomal dominant (CLN4B) MIM:162350

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 416 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.81
gnomAD missense Z
1.79
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC5 as an antibody target. Whether an autoantibody or antibody against DNAJC5 could matter depends on whether native DNAJC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC5 is annotated at the cell surface, where native DNAJC5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DNAJC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAJC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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