Seroatlas · Human Serome Atlas

GSK3A

Glycogen synthase kinase-3 alpha

Also known as: GSK3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49840
Gene
GSK3A
Ensembl
ENSG00000105723
Chromosome
19
Canonical length
483 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

483 residues, UniProt reviewed canonical sequence.

>P49840|GSK3A
     1  MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV
    61  GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT
   121  DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY
   181  SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV
   241  CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS
   301  IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK
   361  AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP
   421  PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTPSSQA LTETPTSSDW QSTDATPTLT
   481  NSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSK3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 98 nTPM
  • skeletal muscle: 80 nTPM
  • cerebellum: 70 nTPM
  • hippocampal formation: 63 nTPM
  • amygdala: 62 nTPM
  • basal ganglia: 57 nTPM

Single-cell type

  • brain excitatory neurons: 16 nCPM
  • other brain neurons: 16 nCPM
  • late spermatids: 15 nCPM
  • brain inhibitory neurons: 15 nCPM
  • oligodendrocytes: 12 nCPM
  • ependymal cells: 9 nCPM

Immune cell

  • neutrophil: 1.7 nTPM
  • eosinophil: 1.5 nTPM
  • basophil: 0.9 nTPM
  • MAIT T-cell: 0.9 nTPM
  • intermediate monocyte: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM

Brain region

  • cerebral cortex: 198 nTPM
  • white matter: 113 nTPM
  • hippocampal formation: 98 nTPM
  • pons: 93 nTPM
  • basal ganglia: 93 nTPM
  • thalamus: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.13
gnomAD pLI
1
gnomAD missense Z
3.22
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GSK3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSK3A as an antibody target. Whether an autoantibody or antibody against GSK3A could matter depends on whether native GSK3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSK3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSK3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GSK3A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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