Seroatlas · Human Serome Atlas

WASF2

Actin-binding protein WASF2

Also known as: SCAR2, WASF2_HUMAN, WAVE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6W5
Gene: WASF2
Ensembl: ENSG00000158195
Chromosome: 1
Canonical length: 498 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q9Y6W5|WASF2
     1  MPLVTRNIEP RHLCRQTLPS VRSELECVTN ITLANVIRQL GSLSKYAEDI FGELFTQANT
    61  FASRVSSLAE RVDRLQVKVT QLDPKEEEVS LQGINTRKAF RSSTIQDQKL FDRNSLPVPV
   121  LETYNTCDTP PPLNNLTPYR DDGKEALKFY TDPSYFFDLW KEKMLQDTKD IMKEKRKHRK
   181  EKKDNPNRGN VNPRKIKTRK EEWEKMKMGQ EFVESKEKLG TSGYPPTLVY QNGSIGCVEN
   241  VDASSYPPPP QSDSASSPSP SFSEDNLPPP PAEFSYPVDN QRGSGLAGPK RSSVVSPSHP
   301  PPAPPLGSPP GPKPGFAPPP APPPPPPPMI GIPPPPPPVG FGSPGTPPPP SPPSFPPHPD
   361  FAAPPPPPPP PAADYPTLPP PPLSQPTGGA PPPPPPPPPP GPPPPPFTGA DGQPAIPPPL
   421  SDTTKPKSSL PAVSDARSDL LSAIRQGFQL RRVEEQREQE KRDVVGNDVA TILSRRIAVE
   481  YSDSEDDSSE FDEDDWSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

esophagus: 86 nTPM
blood vessel: 75 nTPM
bone marrow: 57 nTPM
ovary: 55 nTPM
skin: 54 nTPM
adipose tissue: 52 nTPM

Single-cell type

esophageal apical cells: 1,005 nCPM
esophageal suprabasal cells: 692 nCPM
neutrophils: 516 nCPM
platelets: 463 nCPM
urothelial cells: 436 nCPM
esophageal basal cells: 422 nCPM

Immune cell

non-classical monocyte: 113 nTPM
neutrophil: 101 nTPM
intermediate monocyte: 80 nTPM
classical monocyte: 66 nTPM
plasmacytoid DC: 61 nTPM
total PBMC: 59 nTPM

Brain region

medulla oblongata: 110 nTPM
white matter: 88 nTPM
spinal cord: 87 nTPM
midbrain: 87 nTPM
thalamus: 85 nTPM
basal ganglia: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 1.77
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WASF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASF2 as an antibody target. Whether an autoantibody or antibody against WASF2 could matter depends on whether native WASF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASF2 is annotated at the cell surface, where native WASF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WASF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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