Seroatlas · Human Serome Atlas

FEZ2

Fasciculation and elongation protein zeta-2

Also known as: FEZ2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHY8
Gene: FEZ2
Ensembl: ENSG00000171055
Chromosome: 2
Canonical length: 353 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Nucleoli rim,Golgi apparatus,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q9UHY8|FEZ2
     1  MAADGDWQDF YEFQEPARSL LDQENCNASP EPGAEAGAEA GGGADGFPAP ACSLEEKLSL
    61  CFRPSDPGAE PPRTAVRPIT ERSLLQGDEI WNALTDNYGN VMPVDWKSSH TRTLHLLTLN
   121  LSEKGVSDSL LFDTSDDEEL REQLDMHSII VSCVNDEPLF TADQVIEEIE EMMQESPDPE
   181  DDETPTQSDR LSMLSQEIQT LKRSSTGSYE ERVKRLSVSE LNEILEEIET AIKEYSEELV
   241  QQLALRDELE FEKEVKNSFI SVLIEVQNKQ KEHKETAKKK KKLKNGSSQN GKNERSHMPG
   301  TYLTTVIPYE KKNGPPSVED LQILTKILRA MKEDSEKVPS LLTDYILKVL CPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FEZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 100 nTPM
tongue: 73 nTPM
spinal cord: 57 nTPM
adipose tissue: 50 nTPM
cerebral cortex: 48 nTPM
midbrain: 46 nTPM

Single-cell type

epicardial cells: 819 nCPM
syncytiotrophoblasts: 472 nCPM
myonuclei: 417 nCPM
migrating cytotrophoblasts: 289 nCPM
cytotrophoblasts: 256 nCPM
urothelial cells: 237 nCPM

Immune cell

plasmacytoid DC: 16 nTPM
eosinophil: 5.1 nTPM
neutrophil: 4.2 nTPM
classical monocyte: 3.5 nTPM
myeloid DC: 3.5 nTPM
intermediate monocyte: 3.4 nTPM

Brain region

white matter: 51 nTPM
basal ganglia: 42 nTPM
cerebral cortex: 42 nTPM
spinal cord: 40 nTPM
medulla oblongata: 39 nTPM
thalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -1.82
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FEZ2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FEZ2 as an antibody target. Whether an autoantibody or antibody against FEZ2 could matter depends on whether native FEZ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FEZ2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FEZ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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