Seroatlas · Human Serome Atlas

MAP6

Microtubule-associated protein 6

Also known as: FLJ41346, KIAA1878, MAP6_HUMAN, MAP6-N, STOP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JE9
Gene
MAP6
Ensembl
ENSG00000171533
Chromosome
11
Canonical length
813 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

813 residues, UniProt reviewed canonical sequence.

>Q96JE9|MAP6
     1  MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ QQAQPALAPP
    61  SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG RSGPGPGLGS GSTSGPADSV
   121  MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF ERETQYQKDF RAWPLPRRGD HPWIPKPVQI
   181  SAASQASAPI LGAPKRRPQS QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR
   241  KAGPAWIVRR AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS
   301  YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA DNKVIDRRRI
   361  RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK QAVSGQAAKK KSAEGPSTTK
   421  PDDKEQSKEM NNKLAEAKES LAQPVSDSSK TQGPVATEPD KDQGSVVPGL LKGQGPMVQE
   481  PLKKQGSVVP GPPKDLGPMI PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ
   541  SPMVPAKVKD QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS
   601  APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE SAMATAPIKN
   661  QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA PVKNQGPVVP ESVKNQDPIL
   721  PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK
   781  TQGPRDPQLP TVSPLPRVMI PTAPHTEYIE SSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • retina: 89 nTPM
  • choroid plexus: 87 nTPM
  • cerebral cortex: 83 nTPM
  • hypothalamus: 76 nTPM
  • basal ganglia: 75 nTPM
  • pituitary gland: 74 nTPM

Single-cell type

  • cone photoreceptor cells: 308 nCPM
  • thyrotrophs: 285 nCPM
  • podocytes: 259 nCPM
  • lactotrophs: 156 nCPM
  • retinal bipolar cells: 140 nCPM
  • somatotrophs: 139 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • memory B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 101 nTPM
  • hypothalamus: 101 nTPM
  • cerebral cortex: 97 nTPM
  • basal ganglia: 93 nTPM
  • midbrain: 88 nTPM
  • choroid plexus: 87 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.4
gnomAD missense Z
1.39
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP6 as an antibody target. Whether an autoantibody or antibody against MAP6 could matter depends on whether native MAP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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