Seroatlas · Human Serome Atlas

GOLGA2

Golgin subfamily A member 2

Also known as: GM130, GOGA2_HUMAN, golgin-95

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08379
Gene: GOLGA2
Ensembl: ENSG00000167110
Chromosome: 9
Canonical length: 1002 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus
Quaternary structure: Homohexamer

OverviewNCBI Gene

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]

Canonical amino-acid sequenceUniProt

1002 residues, UniProt reviewed canonical sequence.

>Q08379|GOLGA2
     1  MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI KNGSNPETTT
    61  SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM AASQNHDADN VPNLMDETKT
   121  FSSTESLRQL SQQLNGLVCE SATCVNGEGP ASSANLKDLE SRYQQLAVAL DSSYVTNKQL
   181  NITIEKLKQQ NQEITDQLEE EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT
   241  QHAARQKEGE SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
   301  YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ QFSSRCEAPD
   361  ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL KGESAMWRQR MQQMSEQVHT
   421  LREEKECSMS RVQELETSLA ELRNQMAEPP PPEPPAGPSE VEQQLQAEAE HLRKELEGLA
   481  GQLQAQVQDN EGLSRLNREQ EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS
   541  QNRELKEQLA ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
   601  KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL QQQEAQGKAV
   661  AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG LDREEEEDEE EEEEEAVAVP
   721  QPMPSIPEDL ESREAMVAFF NSAVASAEEE QARLRGQLKE QRVRCRRLAH LLASAQKEPE
   781  AAAPAPGTGG DSVCGETHRA LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET
   841  DTIGEYIALY QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
   901  GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR EGSPRDNPTA
   961  QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT VI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GOLGA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 56 nTPM
pancreas: 46 nTPM
esophagus: 41 nTPM
skeletal muscle: 41 nTPM
salivary gland: 38 nTPM
smooth muscle: 38 nTPM

Single-cell type

esophageal apical cells: 300 nCPM
platelets: 198 nCPM
somatotrophs: 189 nCPM
syncytiotrophoblasts: 172 nCPM
corticotrophs: 170 nCPM
esophageal suprabasal cells: 150 nCPM

Immune cell

basophil: 33 nTPM
neutrophil: 25 nTPM
eosinophil: 13 nTPM
plasmacytoid DC: 12 nTPM
NK-cell: 8.3 nTPM
naive B-cell: 7 nTPM

Brain region

choroid plexus: 58 nTPM
pons: 41 nTPM
hypothalamus: 40 nTPM
midbrain: 39 nTPM
medulla oblongata: 37 nTPM
cerebellum: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GOLGA2.

Disease | AllUniProt

Conditions GOLGA2 is implicated in, by any mechanism.

Developmental delay with hypotonia, myopathy, and brain abnormalities (DEDHMB) MIM:620240

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 223 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental delay with hypotonia, myopathy, and brain abnormalities
Neuromuscular disease

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.99
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GOLGA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GOLGA2 as an antibody target. Whether an autoantibody or antibody against GOLGA2 could matter depends on whether native GOLGA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GOLGA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GOLGA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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