Seroatlas · Human Serome Atlas

PPP2R5E

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

Also known as: 2A5E_HUMAN, B56E, B56epsilon

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16537
Gene: PPP2R5E
Ensembl: ENSG00000154001
Chromosome: 14
Canonical length: 467 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol,Mid piece,Principal piece

OverviewNCBI Gene

The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q16537|PPP2R5E
     1  MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL LKDVPSSEQP
    61  ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI TISRGCLTEQ TYPEVVRMVS
   121  CNIFRTLPPS DSNEFDPEED EPTLEASWPH LQLVYEFFIR FLESQEFQPS IAKKYIDQKF
   181  VLQLLELFDS EDPRERDYLK TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE
   241  LLEILGSIIN GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE
   301  PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK CVSSPHFQVA
   361  ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN PAIVALVYNV LKAFMEMNST
   421  MFDELTATYK SDRQREKKKE KEREELWKKL EDLELKRGLR RDGIIPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP2R5E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

retina: 25 nTPM
thyroid gland: 19 nTPM
rectum: 19 nTPM
esophagus: 19 nTPM
thymus: 18 nTPM
skeletal muscle: 17 nTPM

Single-cell type

early spermatids: 438 nCPM
retinal horizontal cells: 399 nCPM
rod photoreceptor cells: 336 nCPM
cone photoreceptor cells: 259 nCPM
neutrophil progenitors: 257 nCPM
esophageal apical cells: 222 nCPM

Immune cell

NK-cell: 4.6 nTPM
memory CD8 T-cell: 2.5 nTPM
memory CD4 T-cell: 2.2 nTPM
gdT-cell: 2 nTPM
MAIT T-cell: 1.9 nTPM
naive CD8 T-cell: 1.9 nTPM

Brain region

hypothalamus: 32 nTPM
cerebral cortex: 32 nTPM
basal ganglia: 31 nTPM
cerebellum: 30 nTPM
hippocampal formation: 27 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 3.83
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP2R5E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP2R5E as an antibody target. Whether an autoantibody or antibody against PPP2R5E could matter depends on whether native PPP2R5E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP2R5E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP2R5E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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