Seroatlas · Human Serome Atlas

SPRED1

Sprouty-related, EVH1 domain-containing protein 1

Also known as: FLJ33903, PPP1R147, SPRE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z699
Gene
SPRED1
Ensembl
ENSG00000166068
Chromosome
15
Canonical length
444 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

444 residues, UniProt reviewed canonical sequence.

>Q7Z699|SPRED1
     1  MSEETATSDN DNSYARVRAV VMTRDDSSGG WLPLGGSGLS SVTVFKVPHQ EENGCADFFI
    61  RGERLRDKMV VLECMLKKDL IYNKVTPTFH HWKIDDKKFG LTFQSPADAR AFDRGIRRAI
   121  EDISQGCPES KNEAEGADDL QANEEDSSSS LVKDHLFQQE TVVTSEPYRS SNIRPSPFED
   181  LNARRVYMQS QANQITFGQP GLDIQSRSME YVQRQISKEC GSLKSQNRVP LKSIRHVSFQ
   241  DEDEIVRINP RDILIRRYAD YRHPDMWKND LERDDADSSI QFSKPDSKKS DYLYSCGDET
   301  KLSSPKDSVV FKTQPSSLKI KKSKRRKEDG ERSRCVYCQE RFNHEENVRG KCQDAPDPIK
   361  RCIYQVSCML CAESMLYHCM SDSEGDFSDP CSCDTSDDKF CLRWLALVAL SFIVPCMCCY
   421  VPLRMCHRCG EACGCCGGKH KAAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRED1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 29 nTPM
  • cerebral cortex: 19 nTPM
  • basal ganglia: 17 nTPM
  • lung: 16 nTPM
  • amygdala: 14 nTPM
  • placenta: 13 nTPM

Single-cell type

  • microglia: 698 nCPM
  • macrophages: 405 nCPM
  • oligodendrocyte progenitor cells: 395 nCPM
  • hofbauer cells: 385 nCPM
  • bergmann glia: 336 nCPM
  • astrocytes: 227 nCPM

Immune cell

  • non-classical monocyte: 1.4 nTPM
  • intermediate monocyte: 0.7 nTPM
  • myeloid DC: 0.3 nTPM
  • classical monocyte: 0.2 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • basal ganglia: 43 nTPM
  • midbrain: 42 nTPM
  • medulla oblongata: 41 nTPM
  • hypothalamus: 39 nTPM
  • white matter: 38 nTPM
  • cerebral cortex: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPRED1.

Disease | AllUniProt

Conditions SPRED1 is implicated in, by any mechanism.

Disease | GeneticClinVar

166 pathogenic / likely-pathogenic of 1,219 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
1.17
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPRED1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRED1 as an antibody target. Whether an autoantibody or antibody against SPRED1 could matter depends on whether native SPRED1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRED1 is annotated at the cell surface, where native SPRED1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SPRED1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRED1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...