Seroatlas · Human Serome Atlas

CMTR2

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Also known as: AFT, CMTR2_HUMAN, FLJ11171, FTSJD1, MTr2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IYT2
Gene: CMTR2
Ensembl: ENSG00000180917
Chromosome: 16
Canonical length: 770 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nuclear speckles,Cell Junctions

OverviewNCBI Gene

Enables mRNA (nucleoside-2'-O-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

770 residues, UniProt reviewed canonical sequence.

>Q8IYT2|CMTR2
     1  MSKCRKTPVQ QLASPASFSP DILADIFELF AKNFSYGKPL NNEWQLPDPS EIFTCDHTEL
    61  NAFLDLKNSL NEVKNLLSDK KLDEWHEHTA FTNKAGKIIS HVRKSVNAEL CTQAWCKFHE
   121  ILCSFPLIPQ EAFQNGKLNS LHLCEAPGAF IASLNHYLKS HRFPCHWSWV ANTLNPYHEA
   181  NDDLMMIMDD RLIANTLHWW YFGPDNTGDI MTLKFLTGLQ NFISSMATVH LVTADGSFDC
   241  QGNPGEQEAL VSSLHYCEVV TALTTLGNGG SFVLKMFTMF EHCSINLMYL LNCCFDQVHV
   301  FKPATSKAGN SEVYVVCLHY KGREAIHPLL SKMTLNFGTE MKRKALFPHH VIPDSFLKRH
   361  EECCVFFHKY QLETISENIR LFECMGKAEQ EKLNNLRDCA IQYFMQKFQL KHLSRNNWLV
   421  KKSSIGCSTN TKWFGQRNKY FKTYNERKML EALSWKDKVA KGYFNSWAEE HGVYHPGQSS
   481  ILEGTASNLE CHLWHILEGK KLPKVKCSPF CNGEILKTLN EAIEKSLGGA FNLDSKFRPK
   541  QQYSCSCHVF SEELIFSELC SLTECLQDEQ VVVPSNQIKC LLVGFSTLRN IKMHIPLEVR
   601  LLESAELTTF SCSLLHDGDP TYQRLFLDCL LHSLRELHTG DVMILPVLSC FTRFMAGLIF
   661  VLHSCFRFIT FVCPTSSDPL RTCAVLLCVG YQDLPNPVFR YLQSVNELLS TLLNSDSPQQ
   721  VLQFVPMEVL LKGALLDFLW DLNAAIAKRH LHFIIQRERE EIINSLQLQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

tonsil: 17 nTPM
breast: 15 nTPM
duodenum: 14 nTPM
esophagus: 13 nTPM
lymph node: 13 nTPM
small intestine: 13 nTPM

Single-cell type

microglia: 55 nCPM
distal convoluted tubule cells: 36 nCPM
choroid plexus epithelial cells: 35 nCPM
bergmann glia: 26 nCPM
oligodendrocytes: 25 nCPM
proximal tubule cells: 25 nCPM

Immune cell

basophil: 23 nTPM
NK-cell: 17 nTPM
myeloid DC: 14 nTPM
MAIT T-cell: 13 nTPM
memory B-cell: 13 nTPM
naive B-cell: 12 nTPM

Brain region

choroid plexus: 18 nTPM
white matter: 15 nTPM
spinal cord: 12 nTPM
medulla oblongata: 12 nTPM
hypothalamus: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

methyltransferase cap1 activity
methyltransferase cap2 activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosomal RNA methyltransferase, FtsJ domain
S-adenosyl-L-methionine-dependent methyltransferase superfamily
mRNA Cap 2'-O-Ribose Methyltransferase
FtsJ-like methyltransferase
Adrift-type ribose 2-O-methyltransferase domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTR2 as an antibody target. Whether an autoantibody or antibody against CMTR2 could matter depends on whether native CMTR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMTR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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