Seroatlas · Human Serome Atlas

NCBP3

Nuclear cap-binding protein subunit 3

Also known as: C17orf85, ELG, HSA277841, NCBP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53F19
Gene: NCBP3
Ensembl: ENSG00000074356
Chromosome: 17
Canonical length: 620 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Enables RNA 7-methylguanosine cap binding activity and mRNA binding activity. Involved in defense response to virus; mRNA export from nucleus; and snRNA export from nucleus. Located in cytoplasm and nuclear speck. Part of nuclear cap binding activity complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q53F19|NCBP3
     1  MAAVRGLRVS VKAEAPAGPA LGLPSPEAES GVDRGEPEPM EVEEGELEIV PVRRSLKELI
    61  PDTSRRYENK AGSFITGIDV TSKEAIEKKE QRAKRFHFRS EVNLAQRNVA LDRDMMKKAI
   121  PKVRLETIYI CGVDEMSTQD VFSYFKEYPP AHIEWLDDTS CNVVWLDEMT ATRALINMSS
   181  LPAQDKIRSR DASEDKSAEK RKKDKQEDSS DDDEAEEGEV EDENSSDVEL DTLSQVEEES
   241  LLRNDLRPAN KLAKGNRLFM RFATKDDKKE LGAARRSQYY MKYGNPNYGG MKGILSNSWK
   301  RRYHSRRIQR DVIKKRALIG DDVGLTSYKH RHSGLVNVPE EPIEEEEEEE EEEEEEEEED
   361  QDMDADDRVV VEYHEELPAL KQPRERSASR RSSASSSDSD EMDYDLELKM ISTPSPKKSM
   421  KMTMYADEVE SQLKNIRNSM RADSVSSSNI KNRIGNKLPP EKFADVRHLL DEKRQHSRPR
   481  PPVSSTKSDI RQRLGKRPHS PEKAFSSNPV VRREPSSDVH SRLGVPRQDS KGLYADTREK
   541  KSGNLWTRLG SAPKTKEKNT KKVDHRAPGA EEDDSELQRA WGALIKEKEQ SRQKKSRLDN
   601  LPSLQIEVSR ESSSGSEAES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NCBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

testis: 16 nTPM
bone marrow: 16 nTPM
thymus: 13 nTPM
pancreas: 12 nTPM
skin: 11 nTPM
ovary: 11 nTPM

Single-cell type

cytotrophoblasts: 168 nCPM
neutrophil progenitors: 156 nCPM
syncytiotrophoblasts: 144 nCPM
oligodendrocytes: 96 nCPM
neutrophils: 88 nCPM
monocyte progenitors: 69 nCPM

Immune cell

T-reg: 3.2 nTPM
memory CD8 T-cell: 3 nTPM
naive CD4 T-cell: 3 nTPM
neutrophil: 2.8 nTPM
eosinophil: 2.6 nTPM
naive CD8 T-cell: 2.5 nTPM

Brain region

white matter: 28 nTPM
basal ganglia: 19 nTPM
midbrain: 18 nTPM
pons: 18 nTPM
cerebral cortex: 17 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleotide-binding alpha-beta plait domain superfamily
Nuclear cap-binding protein subunit 3
Nuclear cap-binding protein subunit 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NCBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NCBP3 as an antibody target. Whether an autoantibody or antibody against NCBP3 could matter depends on whether native NCBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NCBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NCBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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