Seroatlas · Human Serome Atlas

EXOSC8

Exosome complex component RRP43

Also known as: bA421P11.3, CIP3, EAP2, EXOS8_HUMAN, OIP2, p9, RRP43, Rrp43p

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96B26
Gene
EXOSC8
Ensembl
ENSG00000120699
Chromosome
13
Canonical length
276 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Mitotic chromosome,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

276 residues, UniProt reviewed canonical sequence.

>Q96B26|EXOSC8
     1  MAAGFKTVEP LEYYRRFLKE NCRPDGRELG EFRTTTVNIG SISTADGSAL VKLGNTTVIC
    61  GVKAEFAAPS TDAPDKGYVV PNVDLPPLCS SRFRSGPPGE EAQVASQFIA DVIENSQIIQ
   121  KEDLCISPGK LVWVLYCDLI CLDYDGNILD ACTFALLAAL KNVQLPEVTI NEETALAEVN
   181  LKKKSYLNIR THPVATSFAV FDDTLLIVDP TGEEEHLATG TLTIVMDEEG KLCCLHKPGG
   241  SGLTGAKLQD CMSRAVTRHK EVKKLMDEVI KSMKPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOSC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 29 nTPM
  • bone marrow: 28 nTPM
  • testis: 27 nTPM
  • tonsil: 24 nTPM
  • tongue: 23 nTPM
  • skeletal muscle: 22 nTPM

Single-cell type

  • late primary spermatocytes: 265 nCPM
  • cardiomyocytes: 145 nCPM
  • early primary spermatocytes: 126 nCPM
  • oocytes: 124 nCPM
  • migrating cytotrophoblasts: 118 nCPM
  • early spermatids: 117 nCPM

Immune cell

  • naive CD4 T-cell: 68 nTPM
  • memory B-cell: 67 nTPM
  • naive CD8 T-cell: 64 nTPM
  • naive B-cell: 59 nTPM
  • plasmacytoid DC: 56 nTPM
  • T-reg: 55 nTPM

Brain region

  • white matter: 11 nTPM
  • medulla oblongata: 8.4 nTPM
  • cerebral cortex: 8.1 nTPM
  • cerebellum: 7.9 nTPM
  • basal ganglia: 7.4 nTPM
  • hypothalamus: 7.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOSC8.

Disease | AllUniProt

Conditions EXOSC8 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 138 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.85
DepMap mean gene effect
-1.1
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOSC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOSC8 as an antibody target. Whether an autoantibody or antibody against EXOSC8 could matter depends on whether native EXOSC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOSC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOSC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOSC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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