Seroatlas · Human Serome Atlas

AKAP8L

A-kinase anchor protein 8-like

Also known as: AKP8L_HUMAN, HAP95, NAKAP95

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULX6
Gene
AKAP8L
Ensembl
ENSG00000011243
Chromosome
19
Canonical length
646 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Enables histone deacetylase binding activity and lamin binding activity. Involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Located in chromatin; cytoplasm; and nuclear lumen. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>Q9ULX6|AKAP8L
     1  MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG YGQDNTTNYG
    61  YGMATSHSWE MPSSDTNANT SASGSASADS VLSRINQRLD MVPHLETDMM QGGVYGSGGE
   121  RYDSYESCDS RAVLSERDLY RSGYDYSELD PEMEMAYEGQ YDAYRDQFRM RGNDTFGPRA
   181  QGWARDARSG RPMASGYGRM WEDPMGARGQ CMSGASRLPS LFSQNIIPEY GMFQGMRGGG
   241  AFPGGSRFGF GFGNGMKQMR RTWKTWTTAD FRTKKKKRKQ GGSPDEPDSK ATRTDCSDNS
   301  DSDNDEGTEG EATEGLEGTE AVEKGSRVDG EDEEGKEDGR EEGKEDPEKG ALTTQDENGQ
   361  TKRKLQAGKK SQDKQKKRQR DRMVERIQFV CSLCKYRTFY EDEMASHLDS KFHKEHFKYV
   421  GTKLPKQTAD FLQEYVTNKT KKTEELRKTV EDLDGLIQQI YRDQDLTQEI AMEHFVKKVE
   481  AAHCAACDLF IPMQFGIIQK HLKTMDHNRN RRLMMEQSKK SSLMVARSIL NNKLISKKLE
   541  RYLKGENPFT DSPEEEKEQE EAEGGALDEG AQGEAAGISE GAEGVPAQPP VPPEPAPGAV
   601  SPPPPPPPEE EEEGAVPLLG GALQRQIRGI PGLDVEDDEE GGGGAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AKAP8L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 53 nTPM
  • testis: 41 nTPM
  • retina: 35 nTPM
  • cerebellum: 33 nTPM
  • heart muscle: 32 nTPM
  • bone marrow: 31 nTPM

Single-cell type

  • rod photoreceptor cells: 163 nCPM
  • choroid plexus epithelial cells: 141 nCPM
  • early primary spermatocytes: 139 nCPM
  • adrenal cortex cells: 131 nCPM
  • retinal horizontal cells: 128 nCPM
  • proximal tubule cells: 125 nCPM

Immune cell

  • neutrophil: 3.5 nTPM
  • T-reg: 2.8 nTPM
  • naive B-cell: 2.3 nTPM
  • classical monocyte: 1.8 nTPM
  • MAIT T-cell: 1.8 nTPM
  • eosinophil: 1.7 nTPM

Brain region

  • cerebral cortex: 20 nTPM
  • cerebellum: 19 nTPM
  • white matter: 18 nTPM
  • hypothalamus: 18 nTPM
  • basal ganglia: 17 nTPM
  • thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.03
gnomAD missense Z
1.03
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AKAP8L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AKAP8L as an antibody target. Whether an autoantibody or antibody against AKAP8L could matter depends on whether native AKAP8L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AKAP8L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AKAP8L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AKAP8L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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