Seroatlas · Human Serome Atlas

SNRPD1

Small nuclear ribonucleoprotein Sm D1

Also known as: HsT2456, Sm-D1, SMD1_HUMAN, SNRPD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62314
Gene
SNRPD1
Ensembl
ENSG00000167088
Chromosome
18
Canonical length
119 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>P62314|SNRPD1
     1  MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR EPVQLETLSI
    61  RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR GRGRGRGRGR GRGRGGPRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 89 nTPM
  • thymus: 74 nTPM
  • lymph node: 68 nTPM
  • tonsil: 67 nTPM
  • esophagus: 62 nTPM
  • appendix: 51 nTPM

Single-cell type

  • migrating cytotrophoblasts: 638 nCPM
  • extravillous trophoblasts: 617 nCPM
  • esophageal basal cells: 555 nCPM
  • gastric progenitor cells: 528 nCPM
  • cytotrophoblasts: 484 nCPM
  • esophageal suprabasal cells: 352 nCPM

Immune cell

  • plasmacytoid DC: 225 nTPM
  • myeloid DC: 222 nTPM
  • memory B-cell: 206 nTPM
  • naive B-cell: 196 nTPM
  • T-reg: 194 nTPM
  • non-classical monocyte: 191 nTPM

Brain region

  • midbrain: 22 nTPM
  • hypothalamus: 22 nTPM
  • cerebellum: 20 nTPM
  • pons: 20 nTPM
  • cerebral cortex: 20 nTPM
  • spinal cord: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRPD1.

Disease | ImmuneIEDB

Conditions an epitope on SNRPD1 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against SNRPD1 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for SNRPD1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

6 publications

Show 1 more

Reference: B cellIEDB

12 publications

Show 7 more

Reference: T cellIEDB

3 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.8
gnomAD missense Z
2.29
DepMap mean gene effect
-2.6
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPD1 as an antibody target. Whether an autoantibody or antibody against SNRPD1 could matter depends on whether native SNRPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNRPD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...