Seroatlas · Human Serome Atlas

SNRPB

Small nuclear ribonucleoprotein-associated proteins B and B'

Also known as: COD, RSMB_HUMAN, Sm-B/B', SmB/SmB', snRNP-B, SNRPB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14678
Gene
SNRPB
Ensembl
ENSG00000125835
Chromosome
20
Canonical length
240 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>P14678|SNRPB
     1  MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNSKQAE
    61  REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGIGRAA GRGIPAGVPM
   121  PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAAAATAS IAGAPTQYPP GRGGPPPPMG
   181  RGAPPPGMMG PPPGMRPPMG PPMGIPPGRG TPMGMPPPGM RPPPPGMRGP PPPGMRPPRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
312 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 312 nTPM
  • esophagus: 181 nTPM
  • thymus: 155 nTPM
  • lymph node: 153 nTPM
  • skin: 151 nTPM
  • tonsil: 142 nTPM

Single-cell type

  • extravillous trophoblasts: 752 nCPM
  • esophageal basal cells: 670 nCPM
  • migrating cytotrophoblasts: 609 nCPM
  • early primary spermatocytes: 430 nCPM
  • cytotrophoblasts: 414 nCPM
  • basal keratinocytes: 413 nCPM

Immune cell

  • total PBMC: 266 nTPM
  • T-reg: 242 nTPM
  • plasmacytoid DC: 238 nTPM
  • myeloid DC: 227 nTPM
  • non-classical monocyte: 222 nTPM
  • memory B-cell: 211 nTPM

Brain region

  • white matter: 34 nTPM
  • cerebellum: 32 nTPM
  • spinal cord: 31 nTPM
  • choroid plexus: 30 nTPM
  • cerebral cortex: 29 nTPM
  • medulla oblongata: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRPB.

Disease | AllUniProt

Conditions SNRPB is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 168 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on SNRPB was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against SNRPB are reported. Each links to that disease's full target list.

Showing 20 of 30 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for SNRPB from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

550 publications

Show 20 more of 550 total

Reference: B cellIEDB

4 publications

Reference: T cellIEDB

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.71
gnomAD missense Z
1.87
DepMap mean gene effect
-1.77
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPB as an antibody target. Whether an autoantibody or antibody against SNRPB could matter depends on whether native SNRPB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein.

Canonical record: https://seroatlas.com/gene/SNRPB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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