Seroatlas · Human Serome Atlas

SNRPD2

Small nuclear ribonucleoprotein Sm D2

Also known as: Sm-D2, SMD2_HUMAN, SNRPD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62316
Gene: SNRPD2
Ensembl: ENSG00000125743
Chromosome: 19
Canonical length: 118 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P62316|SNRPD2
     1  MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK KLLGRVKAFD
    61  RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF LRGDSVIVVL RNPLIAGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 537 nTPM

Expression across tissuesHPA

Tissue

ovary: 537 nTPM
thymus: 466 nTPM
bone marrow: 451 nTPM
lymph node: 413 nTPM
tonsil: 380 nTPM
choroid plexus: 379 nTPM

Single-cell type

late spermatids: 1,769 nCPM
esophageal basal cells: 1,042 nCPM
extravillous trophoblasts: 931 nCPM
decidual stromal cells: 919 nCPM
esophageal suprabasal cells: 854 nCPM
migrating cytotrophoblasts: 844 nCPM

Immune cell

total PBMC: 1,780 nTPM
memory B-cell: 1,316 nTPM
naive CD4 T-cell: 1,249 nTPM
naive B-cell: 1,163 nTPM
T-reg: 1,149 nTPM
naive CD8 T-cell: 1,087 nTPM

Brain region

hypothalamus: 140 nTPM
thalamus: 134 nTPM
basal ganglia: 133 nTPM
cerebral cortex: 128 nTPM
medulla oblongata: 125 nTPM
pons: 123 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRPD2.

Disease | ImmuneIEDB

Conditions an epitope on SNRPD2 was assayed in.

systemic lupus erythematosus B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.8
gnomAD missense Z: 2.23
DepMap mean gene effect: -2.12
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPD2 as an antibody target. Whether an autoantibody or antibody against SNRPD2 could matter depends on whether native SNRPD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRPD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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