Seroatlas · Human Serome Atlas

SNRPE

Small nuclear ribonucleoprotein E

Also known as: RUXE_HUMAN, Sm-E

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62304
Gene
SNRPE
Ensembl
ENSG00000182004
Chromosome
1
Canonical length
92 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P62304|SNRPE
     1  MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD
    61  AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 93 nTPM
  • ovary: 83 nTPM
  • bone marrow: 82 nTPM
  • breast: 61 nTPM
  • epididymis: 56 nTPM
  • tonsil: 54 nTPM

Single-cell type

  • gastric progenitor cells: 660 nCPM
  • migrating cytotrophoblasts: 653 nCPM
  • extravillous trophoblasts: 571 nCPM
  • oocytes: 507 nCPM
  • cytotrophoblasts: 437 nCPM
  • esophageal basal cells: 363 nCPM

Immune cell

  • plasmacytoid DC: 46 nTPM
  • NK-cell: 37 nTPM
  • myeloid DC: 34 nTPM
  • MAIT T-cell: 30 nTPM
  • naive CD4 T-cell: 27 nTPM
  • memory CD4 T-cell: 27 nTPM

Brain region

  • choroid plexus: 39 nTPM
  • cerebellum: 38 nTPM
  • white matter: 37 nTPM
  • hypothalamus: 33 nTPM
  • spinal cord: 33 nTPM
  • pons: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNRPE.

Disease | AllUniProt

Conditions SNRPE is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 36 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.91
gnomAD missense Z
1.32
DepMap mean gene effect
-1.92
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPE as an antibody target. Whether an autoantibody or antibody against SNRPE could matter depends on whether native SNRPE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis.

Canonical record: https://seroatlas.com/gene/SNRPE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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