Seroatlas · Human Serome Atlas

SNRPD3

Small nuclear ribonucleoprotein Sm D3

Also known as: Sm-D3, SMD3, SMD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62318
Gene: SNRPD3
Ensembl: ENSG00000100028
Chromosome: 22
Canonical length: 126 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>P62318|SNRPD3
     1  MSIGVPIKVL HEAEGHIVTC ETNTGEVYRG KLIEAEDNMN CQMSNITVTY RDGRVAQLEQ
    61  VYIRGSKIRF LILPDMLKNA PMLKSMKNKN QGSGAGRGKA AILKAQVAAR GRGRGMGRGN
   121  IFQKRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 97 nTPM
tongue: 80 nTPM
thymus: 69 nTPM
liver: 60 nTPM
retina: 50 nTPM
tonsil: 49 nTPM

Single-cell type

enterocytes: 106 nCPM
enteric transient amplifying cells: 85 nCPM
gastric progenitor cells: 83 nCPM
enteric stem cells: 67 nCPM
fallopian tube ciliated cells: 58 nCPM
paneth cells: 58 nCPM

Immune cell

memory B-cell: 61 nTPM
myeloid DC: 54 nTPM
eosinophil: 54 nTPM
non-classical monocyte: 52 nTPM
NK-cell: 51 nTPM
naive B-cell: 51 nTPM

Brain region

white matter: 56 nTPM
cerebellum: 55 nTPM
cerebral cortex: 48 nTPM
hypothalamus: 48 nTPM
choroid plexus: 48 nTPM
pons: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.86
gnomAD missense Z: 2.36
DepMap mean gene effect: -4.25
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sm domain, eukaryotic/archaea-type
LSM domain superfamily
Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3
Sm domain
LSM domain
Small nuclear ribonucleoprotein Sm D3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPD3 as an antibody target. Whether an autoantibody or antibody against SNRPD3 could matter depends on whether native SNRPD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRPD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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