Seroatlas · Human Serome Atlas

SF3A2

Splicing factor 3A subunit 2

Also known as: Prp11, PRPF11, SAP62, SF3A2_HUMAN, SF3a66

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15428
Gene
SF3A2
Ensembl
ENSG00000104897
Chromosome
19
Canonical length
464 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q15428|SF3A2
     1  MDFQHRPGGK TGSGGVASSS ESNRDRRERL RQLALETIDI NKDPYFMKNH LGSYECKLCL
    61  TLHNNEGSYL AHTQGKKHQT NLARRAAKEA KEAPAQPAPE KVKVEVKKFV KIGRPGYKVT
   121  KQRDSEMGQQ SLLFQIDYPE IAEGIMPRHR FMSAYEQRIE PPDRRWQYLL MAAEPYETIA
   181  FKVPSREIDK AEGKFWTHWN RETKQFFLQF HFKMEKPPAP PSLPAGPPGV KRPPPPLMNG
   241  LPPRPPLPES LPPPPPGGLP LPPMPPTGPA PSGPPGPPQL PPPAPGVHPP APVVHPPASG
   301  VHPPAPGVHP PAPGVHPPAP GVHPPTSGVH PPAPGVHPPA PGVHPPAPGV HPPAPGVHPP
   361  APGVHPPPSA GVHPQAPGVH PAAPAVHPQA PGVHPPAPGM HPQAPGVHPQ PPGVHPSAPG
   421  VHPQPPGVHP SNPGVHPPTP MPPMLRPPLP SEGPGNIPPP PPTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SF3A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 89 nTPM
  • testis: 87 nTPM
  • endometrium: 74 nTPM
  • skin: 71 nTPM
  • cervix: 66 nTPM
  • cerebellum: 62 nTPM

Single-cell type

  • late spermatids: 155 nCPM
  • extravillous trophoblasts: 102 nCPM
  • migrating cytotrophoblasts: 95 nCPM
  • oocytes: 92 nCPM
  • cytotrophoblasts: 87 nCPM
  • ovarian stromal cells: 82 nCPM

Immune cell

  • eosinophil: 7.2 nTPM
  • memory CD8 T-cell: 3 nTPM
  • T-reg: 3 nTPM
  • gdT-cell: 2.9 nTPM
  • intermediate monocyte: 2.5 nTPM
  • plasmacytoid DC: 2.5 nTPM

Brain region

  • cerebellum: 62 nTPM
  • cerebral cortex: 51 nTPM
  • white matter: 51 nTPM
  • medulla oblongata: 51 nTPM
  • basal ganglia: 46 nTPM
  • hypothalamus: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.88
gnomAD missense Z
2.61
DepMap mean gene effect
-1.43
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SF3A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SF3A2 as an antibody target. Whether an autoantibody or antibody against SF3A2 could matter depends on whether native SF3A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SF3A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SF3A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SF3A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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