Seroatlas · Human Serome Atlas

BCAS2

Pre-mRNA-splicing factor SPF27

Also known as: DAM1, Snt309, SPF27, SPF27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75934
Gene: BCAS2
Ensembl: ENSG00000116752
Chromosome: 1
Canonical length: 225 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Centrosome
Quaternary structure: Homotetramer

OverviewNCBI Gene

Involved in mRNA splicing, via spliceosome. Located in DNA replication factor A complex; centrosome; and nuclear speck. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. Implicated in breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>O75934|BCAS2
     1  MAGTGLVAGE VVVDALPYFD QGYEAPGVRE AAAALVEEET RRYRPTKNYL SYLTAPDYSA
    61  FETDIMRNEF ERLAARQPIE LLSMKRYELP APSSGQKNDI TAWQECVNNS MAQLEHQAVR
   121  IENLELMSQH GCNAWKVYNE NLVHMIEHAQ KELQKLRKHI QDLNWQRKNM QLTAGSKLRE
   181  MESNWVSLVS KNYEIERTIV QLENEIYQIK QQHGEANKEN IRQDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 72 nTPM
skeletal muscle: 53 nTPM
liver: 48 nTPM
hypothalamus: 47 nTPM
cerebral cortex: 47 nTPM
epididymis: 47 nTPM

Single-cell type

oocytes: 410 nCPM
ocular epithelial cells: 254 nCPM
esophageal basal cells: 243 nCPM
ovarian stromal cells: 243 nCPM
endometrial glandular cells: 235 nCPM
esophageal suprabasal cells: 231 nCPM

Immune cell

MAIT T-cell: 79 nTPM
T-reg: 78 nTPM
NK-cell: 75 nTPM
naive CD4 T-cell: 74 nTPM
total PBMC: 73 nTPM
naive CD8 T-cell: 72 nTPM

Brain region

hypothalamus: 43 nTPM
cerebral cortex: 42 nTPM
pons: 42 nTPM
midbrain: 41 nTPM
white matter: 39 nTPM
cerebellum: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -1.33
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pre-mRNA-splicing factor SPF27
Breast carcinoma amplified sequence 2 (BCAS2)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCAS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCAS2 as an antibody target. Whether an autoantibody or antibody against BCAS2 could matter depends on whether native BCAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCAS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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