Seroatlas · Human Serome Atlas

BAG4

BAG family molecular chaperone regulator 4

Also known as: BAG4_HUMAN, SODD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95429
Gene: BAG4
Ensembl: ENSG00000156735
Chromosome: 8
Canonical length: 457 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>O95429|BAG4
     1  MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET
    61  TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ EQPPYPSYNS NYWNSTARSR APYPSTYPVR
   121  PELQGQSLNS YTNGAYGPTY PPGPGANTAS YSGAYYAPGY TQTSYSTEVP STYRSSGNSP
   181  TPVSRWIYPQ QDCQTEAPPL RGQVPGYPPS QNPGMTLPHY PYGDGNRSVP QSGPTVRPQE
   241  DAWASPGAYG MGGRYPWPSS APSAPPGNLY MTESTSPWPS SGSPQSPPSP PVQQPKDSSY
   301  PYSQSDQSMN RHNFPCSVHQ YESSGTVNND DSDLLDSQVQ YSAEPQLYGN ATSDHPNNQD
   361  QSSSLPEECV PSDESTPPSI KKIIHVLEKV QYLEQEVEEF VGKKTDKAYW LLEEMLTKEL
   421  LELDSVETGG QDSVRQARKE AVCKIQAILE KLEKKGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 27 nTPM
cerebral cortex: 17 nTPM
liver: 16 nTPM
cerebellum: 15 nTPM
skeletal muscle: 14 nTPM
basal ganglia: 11 nTPM

Single-cell type

neutrophil progenitors: 117 nCPM
monocyte progenitors: 65 nCPM
adipocytes: 63 nCPM
cone photoreceptor cells: 58 nCPM
kupffer cells: 50 nCPM
distal convoluted tubule cells: 48 nCPM

Immune cell

non-classical monocyte: 21 nTPM
basophil: 17 nTPM
eosinophil: 15 nTPM
classical monocyte: 14 nTPM
myeloid DC: 13 nTPM
intermediate monocyte: 12 nTPM

Brain region

cerebral cortex: 47 nTPM
basal ganglia: 41 nTPM
cerebellum: 38 nTPM
thalamus: 36 nTPM
white matter: 35 nTPM
hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAG4 as an antibody target. Whether an autoantibody or antibody against BAG4 could matter depends on whether native BAG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAG4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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