Seroatlas · Human Serome Atlas

EPC2

Enhancer of polycomb homolog 2

Also known as: DKFZP566F2124, EPC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q52LR7
Gene: EPC2
Ensembl: ENSG00000135999
Chromosome: 2
Canonical length: 807 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

807 residues, UniProt reviewed canonical sequence.

>Q52LR7|EPC2
     1  MSKLSFRARA LDAAKPLPIY RGKDMPDLND CVSINRAVPQ MPTGMEKEEE SEHHLQRAIS
    61  AQQVFREKKE SMVIPVPEAE SNVNYYNRLY KGEFKQPKQF IHIQPFNLDN EQPDYDMDSE
   121  DETLLNRLNR KMEIKPLQFE IMIDRLEKAS SNQLVTLQEA KLLLNEDDYL IKAVYDYWVR
   181  KRKNCRGPSL IPQIKQEKRD GSTNNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRE
   241  FSRAITILEM IKRREKTKRE LLHLTLEVVE KRYHLGDYGG EILNEVKISR SEKELYATPA
   301  TLHNGNHHKV QECKTKHPHH LSLKEEASDV VRQKKKYPKK PKAEALITSQ QPTPETLPVI
   361  NKSDIKQYDF HSSDEDEFPQ VLSPVSEPEE ENDPDGPCAF RRRAGCQYYA PRLDQANHSC
   421  ENSELADLDK LRYRHCLTTL TVPRRCIGFA RRRIGRGGRV IMDRISTEHD PVLKQIDPEM
   481  LNSFSSSSQT IDFSSNFSRT NASSKHCENR LSLSEILSNI RSCRLQCFQP RLLNLQDSDS
   541  EECTSRKPGQ TVNNKRVSAA SVALLNTSKN GISVTGGITE EQFQTHQQQL VQMQRQQLAQ
   601  LQQKQQSQHS SQQTHPKAQG SSTSDCMSKT LDSASAHFAA SAVVSAPVPS RSEVAKEQNT
   661  GHNNINGVVQ PSGTSKTLYS TNMALSSSPG ISAVQLVRTV GHTTTNHLIP ALCTSSPQTL
   721  PMNNSCLTNA VHLNNVSVVS PVNVHINTRT SAPSPTALKL ATVAASMDRV PKVTPSSAIS
   781  SIARENHEPE RLGLNGIAET TVAMEVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 47 nTPM
ovary: 27 nTPM
endometrium: 24 nTPM
thymus: 22 nTPM
blood vessel: 19 nTPM
thyroid gland: 18 nTPM

Single-cell type

pituicytes/fscs: 244 nCPM
somatotrophs: 244 nCPM
neutrophils: 242 nCPM
lactotrophs: 236 nCPM
thyrotrophs: 226 nCPM
neutrophil progenitors: 217 nCPM

Immune cell

neutrophil: 4.5 nTPM
non-classical monocyte: 2.1 nTPM
naive CD4 T-cell: 1.5 nTPM
memory CD4 T-cell: 1.4 nTPM
T-reg: 1.4 nTPM
MAIT T-cell: 1.3 nTPM

Brain region

cerebellum: 55 nTPM
white matter: 39 nTPM
cerebral cortex: 34 nTPM
hypothalamus: 33 nTPM
basal ganglia: 32 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 2.7
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPC2 as an antibody target. Whether an autoantibody or antibody against EPC2 could matter depends on whether native EPC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EPC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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