Seroatlas · Human Serome Atlas

DMAP1

DNA methyltransferase 1-associated protein 1

Also known as: DMAP1_HUMAN, DNMAP1, DNMTAP1, EAF2, FLJ11543, KIAA1425, MEAF2, SWC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPF5
Gene
DMAP1
Ensembl
ENSG00000178028
Chromosome
1
Canonical length
467 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q9NPF5|DMAP1
     1  MATGADVRDI LELGGPEGDA ASGTISKKDI INPDKKKSKK SSETLTFKRP EGMHREVYAL
    61  LYSDKKDAPP LLPSDTGQGY RTVKAKLGSK KVRPWKWMPF TNPARKDGAM FFHWRRAAEE
   121  GKDYPFARFN KTVQVPVYSE QEYQLYLHDD AWTKAETDHL FDLSRRFDLR FVVIHDRYDH
   181  QQFKKRSVED LKERYYHICA KLANVRAVPG TDLKIPVFDA GHERRRKEQL ERLYNRTPEQ
   241  VAEEEYLLQE LRKIEARKKE REKRSQDLQK LITAADTTAE QRRTERKAPK KKLPQKKEAE
   301  KPAVPETAGI KFPDFKSAGV TLRSQRMKLP SSVGQKKIKA LEQMLLELGV ELSPTPTEEL
   361  VHMFNELRSD LVLLYELKQA CANCEYELQM LRHRHEALAR AGVLGGPATP ASGPGPASAE
   421  PAVTEPGLGP DPKDTIIDVV GAPLTPNSRK RRESASSSSS VKKAKKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DMAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
53 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 53 nTPM
  • cerebral cortex: 36 nTPM
  • skeletal muscle: 35 nTPM
  • amygdala: 34 nTPM
  • hippocampal formation: 33 nTPM
  • basal ganglia: 33 nTPM

Single-cell type

  • late spermatids: 101 nCPM
  • cytotrophoblasts: 89 nCPM
  • oocytes: 74 nCPM
  • undifferentiated spermatogonia: 61 nCPM
  • syncytiotrophoblasts: 58 nCPM
  • migrating cytotrophoblasts: 53 nCPM

Immune cell

  • basophil: 45 nTPM
  • NK-cell: 44 nTPM
  • T-reg: 38 nTPM
  • memory CD8 T-cell: 32 nTPM
  • MAIT T-cell: 32 nTPM
  • memory CD4 T-cell: 31 nTPM

Brain region

  • cerebral cortex: 27 nTPM
  • cerebellum: 26 nTPM
  • white matter: 26 nTPM
  • thalamus: 25 nTPM
  • basal ganglia: 24 nTPM
  • hippocampal formation: 24 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DMAP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.04
gnomAD missense Z
2.29
DepMap mean gene effect
-1.14
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • DNA methyltransferase 1-associated 1
  • SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1
  • DAMP1, SANT/Myb-like domain
  • DNA methyltransferase 1-associated protein 1 (DMAP1)
  • SANT/Myb-like domain of DAMP1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DMAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DMAP1 as an antibody target. Whether an autoantibody or antibody against DMAP1 could matter depends on whether native DMAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DMAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DMAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DMAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...