Seroatlas · Human Serome Atlas

EPC1

Enhancer of polycomb homolog 1

Also known as: EPC1_HUMAN, Epl1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2F5
Gene: EPC1
Ensembl: ENSG00000120616
Chromosome: 10
Canonical length: 836 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

836 residues, UniProt reviewed canonical sequence.

>Q9H2F5|EPC1
     1  MSKLSFRARA LDASKPLPVF RCEDLPDLHE YASINRAVPQ MPTGMEKEEE SEHHLQRAIS
    61  AQQVYGEKRD NMVIPVPEAE SNIAYYESIY PGEFKMPKQL IHIQPFSLDA EQPDYDLDSE
   121  DEVFVNKLKK KMDICPLQFE EMIDRLEKGS GQQPVSLQEA KLLLKEDDEL IREVYEYWIK
   181  KRKNCRGPSL IPSVKQEKRD GSSTNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRD
   241  LSRAVTILEM IKRREKSKRE LLHLTLEIME KRYNLGDYNG EIMSEVMAQR QPMKPTYAIP
   301  IIPITNSSQF KHQEAMDVKE FKVNKQDKAD LIRPKRKYEK KPKVLPSSAA ATPQQTSPAA
   361  LPVFNAKDLN QYDFPSSDEE PLSQVLSGSS EAEEDNDPDG PFAFRRKAGC QYYAPHLDQT
   421  GNWPWTSPKD GGLGDVRYRY CLTTLTVPQR CIGFARRRVG RGGRVLLDRA HSDYDSVFHH
   481  LDLEMLSSPQ HSPVNQFANT SETNTSDKSF SKDLSQILVN IKSCRWRHFR PRTPSLHDSD
   541  NDELSCRKLY RSINRTGTAQ PGTQTCSTST QSKSSSGSAH FAFTAEQYQQ HQQQLALMQK
   601  QQLAQIQQQQ ANSNSSTNTS QNLASNQQKS GFRLNIQGLE RTLQGFVSKT LDSASAQFAA
   661  SALVTSEQLM GFKMKDDVVL GIGVNGVLPA SGVYKGLHLS STTPTALVHT SPSTAGSALL
   721  QPSNITQTSS SHSALSHQVT AANSATTQVL IGNNIRLTVP SSVATVNSIA PINARHIPRT
   781  LSAVPSSALK LAAAANCQVS KVPSSSSVDS VPRENHESEK PALNNIADNT VAMEVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 141 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 141 nTPM
thymus: 30 nTPM
skeletal muscle: 29 nTPM
tongue: 22 nTPM
cerebellum: 21 nTPM
lymph node: 20 nTPM

Single-cell type

myonuclei: 586 nCPM
t-cells: 400 nCPM
innate lymphoid cells: 358 nCPM
nk-cells: 354 nCPM
lactotrophs: 321 nCPM
thyrotrophs: 309 nCPM

Immune cell

basophil: 66 nTPM
neutrophil: 47 nTPM
eosinophil: 36 nTPM
naive B-cell: 31 nTPM
memory B-cell: 28 nTPM
plasmacytoid DC: 27 nTPM

Brain region

cerebellum: 38 nTPM
white matter: 27 nTPM
basal ganglia: 22 nTPM
cerebral cortex: 22 nTPM
medulla oblongata: 21 nTPM
midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 2.67
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EPC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EPC1 as an antibody target. Whether an autoantibody or antibody against EPC1 could matter depends on whether native EPC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EPC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EPC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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