Seroatlas · Human Serome Atlas

INO80B

INO80 complex subunit B

Also known as: hIes2, HMGA1L4, HMGIYL4, IES2, IN80B_HUMAN, PAP-1BP, PAPA-1, ZNHIT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C086
Gene
INO80B
Ensembl
ENSG00000115274
Chromosome
2
Canonical length
356 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Nuclear bodies

OverviewNCBI Gene

This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q9C086|INO80B
     1  MSKLWRRGST SGAMEAPEPG EALELSLAGA HGHGVHKKKH KKHKKKHKKK HHQEEDAGPT
    61  QPSPAKPQLK LKIKLGGQVL GTKSVPTFTV IPEGPRSPSP LMVVDNEEEP MEGVPLEQYR
   121  AWLDEDSNLS PSPLRDLSGG LGGQEEEEEQ RWLDALEKGE LDDNGDLKKE INERLLTARQ
   181  RALLQKARSQ PSPMLPLPVA EGCPPPALTE EMLLKREERA RKRRLQAARR AEEHKNQTIE
   241  RLTKTAATSG RGGRGGARGE RRGGRAAAPA PMVRYCSGAQ GSTLSFPPGV PAPTAVSQRP
   301  SPSGPPPRCS VPGCPHPRRY ACSRTGQALC SLQCYRINLQ MRLGGPEGPG SPLLAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INO80B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 49 nTPM
  • pancreas: 46 nTPM
  • pituitary gland: 43 nTPM
  • skin: 43 nTPM
  • thyroid gland: 42 nTPM
  • cerebellum: 37 nTPM

Single-cell type

  • other brain neurons: 7 nCPM
  • ependymal cells: 6.5 nCPM
  • megakaryocytes: 6.2 nCPM
  • brain excitatory neurons: 5.3 nCPM
  • bergmann glia: 5.2 nCPM
  • oligodendrocytes: 5.1 nCPM

Immune cell

  • basophil: 3.3 nTPM
  • neutrophil: 3.2 nTPM
  • plasmacytoid DC: 3.2 nTPM
  • memory B-cell: 2.6 nTPM
  • classical monocyte: 2.5 nTPM
  • T-reg: 2.2 nTPM

Brain region

  • cerebral cortex: 49 nTPM
  • white matter: 48 nTPM
  • basal ganglia: 48 nTPM
  • pons: 46 nTPM
  • amygdala: 45 nTPM
  • midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.76
gnomAD missense Z
0.73
DepMap mean gene effect
-0.45
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INO80B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INO80B as an antibody target. Whether an autoantibody or antibody against INO80B could matter depends on whether native INO80B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INO80B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INO80B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INO80B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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