Seroatlas · Human Serome Atlas

URI1

Unconventional prefoldin RPB5 interactor 1

Also known as: C19orf2, FLJ10575, NNX3, PPP1R19, RMP, RMP_HUMAN, URI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94763
Gene: URI1
Ensembl: ENSG00000105176
Chromosome: 19
Canonical length: 535 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>O94763|URI1
     1  MEAPTVETPP DPSPPSAPAP ALVPLRAPDV ARLREEQEKV VTNCQERIQH WKKVDNDYNA
    61  LRERLSTLPD KLSYNIMVPF GPFAFMPGKL VHTNEVTVLL GDNWFAKCSA KQAVGLVEHR
   121  KEHVRKTIDD LKKVMKNFES RVEFTEDLQK MSDAAGDIVD IREEIKCDFE FKAKHRIAHK
   181  PHSKPKTSDI FEADIANDVK SKDLLADKEL WARLEELERQ EELLGELDSK PDTVIANGED
   241  TTSSEEEKED RNTNVNAMHQ VTDSHTPCHK DVASSEPFSG QVNSQLNCSV NGSSSYHSDD
   301  DDDDDDDDDD DNIDDDDGDN DHEALGVGDN SIPTIYFSHT VEPKRVRINT GKNTTLKFSE
   361  KKEEAKRKRK NSTGSGHSAQ ELPTIRTPAD IYRAFVDVVN GEYVPRKSIL KSRSRENSVC
   421  SDTSESSAAE FDDRRGVLRS ISCEEATCSD TSESILEEEP QENQKKLLPL SVTPEAFSGT
   481  VIEKEFVSPS LTPPPAIAHP ALPTIPERKE VLLEASEETG KRVSKFKAAR LQQKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against URI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 52 nTPM
skeletal muscle: 50 nTPM
testis: 48 nTPM
skin: 42 nTPM
lymph node: 37 nTPM
prostate: 35 nTPM

Single-cell type

late spermatids: 625 nCPM
early spermatids: 478 nCPM
late primary spermatocytes: 385 nCPM
gastric progenitor cells: 314 nCPM
lactotrophs: 260 nCPM
gonadotrophs: 231 nCPM

Immune cell

naive B-cell: 4.6 nTPM
basophil: 3.3 nTPM
naive CD4 T-cell: 3.1 nTPM
naive CD8 T-cell: 3.1 nTPM
memory CD8 T-cell: 3 nTPM
gdT-cell: 2.9 nTPM

Brain region

cerebellum: 130 nTPM
white matter: 102 nTPM
basal ganglia: 90 nTPM
hypothalamus: 85 nTPM
medulla oblongata: 85 nTPM
pons: 82 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -1.25
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Prefoldin alpha-like
Prefoldin
Prefoldin subunit
RNA polymerase II subunit 5-mediating protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of URI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads URI1 as an antibody target. Whether an autoantibody or antibody against URI1 could matter depends on whether native URI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

URI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label URI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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