Seroatlas · Human Serome Atlas

ING3

Inhibitor of growth protein 3

Also known as: Eaf4, FLJ20089, ING3_HUMAN, MEAF4, p47ING3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NXR8
Gene
ING3
Ensembl
ENSG00000071243
Chromosome
7
Canonical length
418 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q9NXR8|ING3
     1  MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE
    61  QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE
   121  RRSLELDTPS QPVNNHHAHS HTPVEKRKYN PTSHHTTTDH IPEKKFKSEA LLSTLTSDAS
   181  KENTLGCRNN NSTASSNNAY NVNSSQPLGS YNIGSLSSGT GAGAITMAAA QAVQATAQMK
   241  EGRRTSSLKA SYEAFKNNDF QLGKEFSMAR ETVGYSSSSA LMTTLTQNAS SSAADSRSGR
   301  KSKNNNKSSS QQSSSSSSSS SLSSCSSSST VVQEISQQTT VVPESDSNSQ VDWTYDPNEP
   361  RYCICNQVSY GEMVGCDNQD CPIEWFHYGC VGLTEAPKGK WYCPQCTAAM KRRGSRHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ING3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 76 nTPM
  • thymus: 17 nTPM
  • spleen: 15 nTPM
  • placenta: 14 nTPM
  • lymph node: 14 nTPM
  • tonsil: 13 nTPM

Single-cell type

  • neutrophils: 98 nCPM
  • neutrophil progenitors: 64 nCPM
  • syncytiotrophoblasts: 60 nCPM
  • monocytes: 54 nCPM
  • monocyte progenitors: 53 nCPM
  • b-cells: 49 nCPM

Immune cell

  • neutrophil: 51 nTPM
  • basophil: 44 nTPM
  • non-classical monocyte: 33 nTPM
  • intermediate monocyte: 31 nTPM
  • NK-cell: 31 nTPM
  • classical monocyte: 28 nTPM

Brain region

  • cerebellum: 24 nTPM
  • white matter: 13 nTPM
  • spinal cord: 11 nTPM
  • midbrain: 11 nTPM
  • cerebral cortex: 11 nTPM
  • pons: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ING3.

Disease | AllUniProt

Conditions ING3 is implicated in, by any mechanism.

  • Squamous cell carcinoma of the head and neck (HNSCC) MIM:275355

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
2.29
DepMap mean gene effect
-0.44
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ING3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ING3 as an antibody target. Whether an autoantibody or antibody against ING3 could matter depends on whether native ING3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ING3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ING3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ING3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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