Seroatlas · Human Serome Atlas

ZNHIT2

Zinc finger HIT domain-containing protein 2

Also known as: C11orf5, FON, ZNHI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHR6
Gene: ZNHIT2
Ensembl: ENSG00000174276
Chromosome: 11
Canonical length: 403 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q9UHR6|ZNHIT2
     1  MEPAGPCGFC PAGEVQPARY TCPRCNAPYC SLRCYRTHGT CAENFYRDQV LGELRGCSAP
    61  PSRLASALRR LRQQRETEDE PGEAGLSSGP APGGLSGLWE RLAPGEKAAF ERLLSRGEAG
   121  RLLPPWRPWW WNRGAGPQLL EELDNAPGSD AAELELAPAR TPPDSVKDAS AAEPAAAERV
   181  LGDVPGACTP VVPTRIPAIV SLSRGPVSPL VRFQLPNVLF AYAHTLALYH GGDDALLSDF
   241  CATLLGVSGA LGAQQVFASA EEALQAAAHV LEAGEHPPGP LGTRGAMHEV ARILLGEGPT
   301  NQKGYTLAAL GDLAQTLGRA RKQAVAREER DHLYRARKKC QFLLAWTNEN EAALTPLALD
   361  CARAHQAHAV VAEEVAALTG ELERLWGGPV PPAPRTLIEE LPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNHIT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

testis: 66 nTPM
adrenal gland: 24 nTPM
pituitary gland: 16 nTPM
liver: 15 nTPM
choroid plexus: 15 nTPM
pancreas: 14 nTPM

Single-cell type

late spermatids: 1,220 nCPM
early spermatids: 347 nCPM
late primary spermatocytes: 253 nCPM
fallopian tube ciliated cells: 80 nCPM
respiratory ciliated cells: 69 nCPM
epididymal efferent duct ciliated cells: 55 nCPM

Immune cell

naive B-cell: 27 nTPM
plasmacytoid DC: 26 nTPM
gdT-cell: 25 nTPM
MAIT T-cell: 25 nTPM
memory CD8 T-cell: 24 nTPM
naive CD8 T-cell: 23 nTPM

Brain region

choroid plexus: 23 nTPM
cerebral cortex: 14 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM
white matter: 12 nTPM
spinal cord: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -1.44
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger, HIT-type
HIT zinc finger
Zinc finger HIT domain-containing protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNHIT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNHIT2 as an antibody target. Whether an autoantibody or antibody against ZNHIT2 could matter depends on whether native ZNHIT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNHIT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNHIT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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