Seroatlas · Human Serome Atlas

ZNHIT6

Box C/D snoRNA protein 1

Also known as: BCD1, BCD1_HUMAN, C1orf181, FLJ20729, NY-BR-75

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWK9
Gene
ZNHIT6
Ensembl
ENSG00000117174
Chromosome
1
Canonical length
470 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Vesicles

OverviewNCBI Gene

Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Involved in box C/D snoRNP assembly; protein complex oligomerization; and snoRNA localization. Located in extracellular exosome. Part of pre-snoRNP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

470 residues, UniProt reviewed canonical sequence.

>Q9NWK9|ZNHIT6
     1  MEFAAENEGK SGGGLHSVAE GVRLSPEPGR EGVRDLAGAE EFGGGEEGTG LTGIKEIGDG
    61  EEGSGQRPEE IPMDLTVVKQ EIIDWPGTEG RLAGQWVEQE VEDRPEVKDE NAGVLEVKQE
   121  TDSSLVVKEA KVGEPEVKEE KVKEEVMDWS EVKEEKDNLE IKQEEKFVGQ CIKEELMHGE
   181  CVKEEKDFLK KEIVDDTKVK EEPPINHPVG CKRKLAMSRC ETCGTEEAKY RCPRCMRYSC
   241  SLPCVKKHKA ELTCNGVRDK TAYISIQQFT EMNLLSDYRF LEDVARTADH ISRDAFLKRP
   301  ISNKYMYFMK NRARRQGINL KLLPNGFTKR KENSTFFDKK KQQFCWHVKL QFPQSQAEYI
   361  EKRVPDDKTI NEILKPYIDP EKSDPVIRQR LKAYIRSQTG VQILMKIEYM QQNLVRYYEL
   421  DPYKSLLDNL RNKVIIEYPT LHVVLKGSNN DMKVLHQVKS ESTKNVGNEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNHIT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
7.2 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 7.2 nTPM
  • midbrain: 6.6 nTPM
  • cervix: 6.4 nTPM
  • breast: 6.2 nTPM
  • blood vessel: 6 nTPM
  • lymph node: 6 nTPM

Single-cell type

  • salivary duct cells: 103 nCPM
  • conjunctival goblet cells: 90 nCPM
  • megakaryocyte-erythroid progenitors: 89 nCPM
  • somatotrophs: 87 nCPM
  • renal collecting duct principal cells: 84 nCPM
  • fibro-adipogenic progenitors: 84 nCPM

Immune cell

  • naive B-cell: 2.4 nTPM
  • MAIT T-cell: 2 nTPM
  • memory CD8 T-cell: 2 nTPM
  • naive CD4 T-cell: 2 nTPM
  • naive CD8 T-cell: 2 nTPM
  • plasmacytoid DC: 2 nTPM

Brain region

  • white matter: 17 nTPM
  • spinal cord: 15 nTPM
  • basal ganglia: 15 nTPM
  • hypothalamus: 15 nTPM
  • medulla oblongata: 14 nTPM
  • thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
-0.8
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNHIT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNHIT6 as an antibody target. Whether an autoantibody or antibody against ZNHIT6 could matter depends on whether native ZNHIT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNHIT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNHIT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNHIT6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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