Seroatlas · Human Serome Atlas

ITFG1

T-cell immunomodulatory protein

Also known as: CDA08, LNKN-1, TIP, TIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TB96
Gene: ITFG1
Ensembl: ENSG00000129636
Chromosome: 16
Canonical length: 612 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

612 residues, UniProt reviewed canonical sequence.

>Q8TB96|ITFG1
     1  MAAAGRLPSS WALFSPLLAG LALLGVGPVP ARALHNVTAE LFGAEAWGTL AAFGDLNSDK
    61  QTDLFVLRER NDLIVFLADQ NAPYFKPKVK VSFKNHSALI TSVVPGDYDG DSQMDVLLTY
   121  LPKNYAKSEL GAVIFWGQNQ TLDPNNMTIL NRTFQDEPLI MDFNGDLIPD IFGITNESNQ
   181  PQILLGGNLS WHPALTTTSK MRIPHSHAFI DLTEDFTADL FLTTLNATTS TFQFEIWENL
   241  DGNFSVSTIL EKPQNMMVVG QSAFADFDGD GHMDHLLPGC EDKNCQKSTI YLVRSGMKQW
   301  VPVLQDFSNK GTLWGFVPFV DEQQPTEIPI PITLHIGDYN MDGYPDALVI LKNTSGSNQQ
   361  AFLLENVPCN NASCEEARRM FKVYWELTDL NQIKDAMVAT FFDIYEDGIL DIVVLSKGYT
   421  KNDFAIHTLK NNFEADAYFV KVIVLSGLCS NDCPRKITPF GVNQPGPYIM YTTVDANGYL
   481  KNGSAGQLSQ SAHLALQLPY NVLGLGRSAN FLDHLYVGIP RPSGEKSIRK QEWTAIIPNS
   541  QLIVIPYPHN VPRSWSAKLY LTPSNIVLLT AIALIGVCVF ILAIIGILHW QEKKADDREK
   601  RQEAHRFHFD AM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITFG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 53 nTPM
cerebral cortex: 50 nTPM
kidney: 45 nTPM
liver: 42 nTPM
heart muscle: 42 nTPM
thyroid gland: 41 nTPM

Single-cell type

sertoli cells: 1,254 nCPM
myonuclei: 661 nCPM
adrenal cortex cells: 606 nCPM
gonadotrophs: 529 nCPM
brain inhibitory neurons: 435 nCPM
cardiomyocytes: 390 nCPM

Immune cell

classical monocyte: 34 nTPM
eosinophil: 34 nTPM
non-classical monocyte: 34 nTPM
intermediate monocyte: 33 nTPM
total PBMC: 29 nTPM
T-reg: 26 nTPM

Brain region

choroid plexus: 72 nTPM
basal ganglia: 66 nTPM
cerebral cortex: 65 nTPM
hypothalamus: 65 nTPM
hippocampal formation: 57 nTPM
white matter: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.07
gnomAD missense Z: 1.63
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

FG-GAP repeat
Integrin alpha, N-terminal
FG-GAP-like repeat
T-cell immunomodulatory protein
T-cell immunomodulatory protein TIP, C2 domain
ITFG1, C2 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITFG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITFG1 as an antibody target. Whether an autoantibody or antibody against ITFG1 could matter depends on whether native ITFG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITFG1 is annotated as secreted, so native ITFG1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ITFG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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