Seroatlas · Human Serome Atlas

EAPP

E2F-associated phosphoprotein

Also known as: BM036, C14orf11, EAPP_HUMAN, FLJ20578

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q56P03
Gene: EAPP
Ensembl: ENSG00000129518
Chromosome: 14
Canonical length: 285 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q56P03|EAPP
     1  MNRLPDDYDP YAVEEPSDEE PALSSSEDEV DVLLHGTPDQ KRKLIRECLT GESESSSEDE
    61  FEKEMEAELN STMKTMEDKL SSLGTGSSSG NGKVATAPTR YYDDIYFDSD SEDEDRAVQV
   121  TKKKKKKQHK IPTNDELLYD PEKDNRDQAW VDAQRRGYHG LGPQRSRQQQ PVPNSDAVLN
   181  CPACMTTLCL DCQRHESYKT QYRAMFVMNC SINKEEVLRY KASENRKKRR VHKKMRSNRE
   241  DAAEKAETDV EEIYHPVMCT ECSTEVAVYD KDEVFHFFNV LASHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EAPP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 84 nTPM
parathyroid gland: 50 nTPM
ovary: 49 nTPM
rectum: 48 nTPM
breast: 47 nTPM
colon: 47 nTPM

Single-cell type

syncytiotrophoblasts: 267 nCPM
neutrophils: 233 nCPM
ovarian stromal cells: 209 nCPM
migrating cytotrophoblasts: 187 nCPM
enterocytes: 177 nCPM
cytotrophoblasts: 169 nCPM

Immune cell

neutrophil: 135 nTPM
basophil: 134 nTPM
eosinophil: 130 nTPM
T-reg: 117 nTPM
memory B-cell: 99 nTPM
NK-cell: 97 nTPM

Brain region

white matter: 28 nTPM
cerebellum: 28 nTPM
hypothalamus: 26 nTPM
spinal cord: 25 nTPM
cerebral cortex: 24 nTPM
choroid plexus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

E2F-associated phosphoprotein
E2F-associated phosphoprotein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EAPP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EAPP as an antibody target. Whether an autoantibody or antibody against EAPP could matter depends on whether native EAPP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EAPP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EAPP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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