Seroatlas · Human Serome Atlas

INO80C

INO80 complex subunit C

Also known as: C18orf37, FLJ38183, hIes6, IES6, IN80C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PI98
Gene: INO80C
Ensembl: ENSG00000153391
Chromosome: 18
Canonical length: 192 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; fibrillar center; and nucleoplasm. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>Q6PI98|INO80C
     1  MAAQIPIVAT TSTPGIVRNS KKRPASPSHN GSSGGGYGAS KKKKASASSF AQGISMEAMS
    61  ENKMVPSEFS TGPVEKAAKP LPFKDPNFVH SGHGGAVAGK KNRTWKNLKQ ILASERALPW
   121  QLNDPNYFSI DAPPSFKPAK KYSDVSGLLA NYTDPQSKLR FSTIEEFSYI RRLPSDVVTG
   181  YLALRKATSI VP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INO80C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

testis: 86 nTPM
esophagus: 45 nTPM
bone marrow: 44 nTPM
skeletal muscle: 40 nTPM
choroid plexus: 39 nTPM
skin: 38 nTPM

Single-cell type

late primary spermatocytes: 89 nCPM
early spermatids: 32 nCPM
gastric chief cells: 28 nCPM
esophageal apical cells: 20 nCPM
suprabasal keratinocytes: 14 nCPM
late spermatids: 13 nCPM

Immune cell

eosinophil: 36 nTPM
plasmacytoid DC: 34 nTPM
memory B-cell: 25 nTPM
neutrophil: 23 nTPM
myeloid DC: 22 nTPM
T-reg: 22 nTPM

Brain region

hypothalamus: 50 nTPM
choroid plexus: 49 nTPM
cerebellum: 35 nTPM
pons: 35 nTPM
basal ganglia: 35 nTPM
cerebral cortex: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INO80C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INO80C as an antibody target. Whether an autoantibody or antibody against INO80C could matter depends on whether native INO80C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INO80C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INO80C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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