Seroatlas · Human Serome Atlas

NOPCHAP1

NOP protein chaperone 1

Also known as: C12orf45, DDSR1, MGC40397, NOPC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5I9
Gene: NOPCHAP1
Ensembl: ENSG00000151131
Chromosome: 12
Canonical length: 185 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Enables box C/D methylation guide snoRNP complex binding activity. Involved in box C/D snoRNP assembly. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q8N5I9|NOPCHAP1
     1  MEVHGKPKAS PSCSSPTRDS SGVPVSKELL TAGSDGRGGI WDRLLINSQP KSRKTSTLQT
    61  VRIERSPLLD QVQTFLPQMA RANEKLRKEM AAAPPGRFNI ENIDGPHSKV IQMDVALFEM
   121  NQSDSKEVDS SEESSQDSSE NSSESEDEDD SIPSEVTIDN IKLPNSEGGK GKIEVLDSPA
   181  SKKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOPCHAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

pancreas: 23 nTPM
stomach: 14 nTPM
liver: 14 nTPM
salivary gland: 14 nTPM
amygdala: 12 nTPM
choroid plexus: 12 nTPM

Single-cell type

pdcs: 238 nCPM
oocytes: 226 nCPM
plasma cells: 127 nCPM
gastric chief cells: 84 nCPM
gastric progenitor cells: 83 nCPM
cdc: 82 nCPM

Immune cell

plasmacytoid DC: 463 nTPM
myeloid DC: 106 nTPM
memory B-cell: 35 nTPM
classical monocyte: 34 nTPM
T-reg: 33 nTPM
intermediate monocyte: 31 nTPM

Brain region

cerebellum: 58 nTPM
cerebral cortex: 54 nTPM
white matter: 52 nTPM
basal ganglia: 50 nTPM
hypothalamus: 50 nTPM
hippocampal formation: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.01
DepMap mean gene effect: -0.74
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

box C/D snoRNP assembly

Molecular functions

box C/D methylation guide snoRNP complex binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

NOP protein chaperone 1
NOP protein chaperone 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOPCHAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOPCHAP1 as an antibody target. Whether an autoantibody or antibody against NOPCHAP1 could matter depends on whether native NOPCHAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOPCHAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOPCHAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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