Seroatlas · Human Serome Atlas

RNF146

E3 ubiquitin-protein ligase RNF146

Also known as: dactylidin, dJ351K20.1, DKFZp434O1427, RN146_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NTX7
Gene
RNF146
Ensembl
ENSG00000118518
Chromosome
6
Canonical length
359 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q9NTX7|RNF146
     1  MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC
    61  VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG NGEYAWYYEG RNGWWQYDER
   121  TSRELEDAFS KGKKNTEMLI AGFLYVADLE NMVQYRRNEH GRRRKIKRDI IDIPKKGVAG
   181  LRLDCDANTV NLARESSADG ADSVSAQSGA SVQPLVSSVR PLTSVDGQLT SPATPSPDAS
   241  TSLEDSFAHL QLSGDNTAER SHRGEGEEDH ESPSSGRVPA PDTSIEETES DASSDSEDVS
   301  AVVAQHSLTQ QRLLVSNANQ TVPDRSDRSG TDRSVAGGGT VSVSVRSRRP DGQCTVTEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF146 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 95 nTPM
  • skeletal muscle: 82 nTPM
  • tongue: 63 nTPM
  • spinal cord: 48 nTPM
  • blood vessel: 42 nTPM
  • midbrain: 42 nTPM

Single-cell type

  • neutrophils: 173 nCPM
  • myonuclei: 168 nCPM
  • kupffer cells: 124 nCPM
  • brain excitatory neurons: 94 nCPM
  • fibro-adipogenic progenitors: 93 nCPM
  • adipocytes: 86 nCPM

Immune cell

  • non-classical monocyte: 35 nTPM
  • neutrophil: 33 nTPM
  • intermediate monocyte: 27 nTPM
  • classical monocyte: 26 nTPM
  • basophil: 25 nTPM
  • eosinophil: 24 nTPM

Brain region

  • cerebellum: 89 nTPM
  • white matter: 67 nTPM
  • medulla oblongata: 62 nTPM
  • basal ganglia: 62 nTPM
  • spinal cord: 61 nTPM
  • thalamus: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.82
gnomAD missense Z
1.33
DepMap mean gene effect
0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF146 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF146 as an antibody target. Whether an autoantibody or antibody against RNF146 could matter depends on whether native RNF146 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF146 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF146 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF146. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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