Seroatlas · Human Serome Atlas

DPCD

Protein DPCD

Also known as: DKFZP566F084, DPCD_HUMAN, RP11-529I10.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVM2
Gene: DPCD
Ensembl: ENSG00000166171
Chromosome: 10
Canonical length: 203 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane,Mitotic spindle,Primary cilium

OverviewNCBI Gene

This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

203 residues, UniProt reviewed canonical sequence.

>Q9BVM2|DPCD
     1  MAVTGWLESL RTAQKTALLQ DGRRKVHYLF PDGKEMAEEY DEKTSELLVR KWRVKSALGA
    61  MGQWQLEVGD PAPLGAGNLG PELIKESNAN PIFMRKDTKM SFQWRIRNLP YPKDVYSVSV
   121  DQKERCIIVR TTNKKYYKKF SIPDLDRHQL PLDDALLSFA HANCTLIISY QKPKEVVVAE
   181  SELQKELKKV KTAHSNDGDC KTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DPCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 142 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 142 nTPM
testis: 136 nTPM
fallopian tube: 69 nTPM
retina: 52 nTPM
pituitary gland: 50 nTPM
amygdala: 48 nTPM

Single-cell type

late spermatids: 1,610 nCPM
late primary spermatocytes: 886 nCPM
early spermatids: 498 nCPM
respiratory ciliated cells: 317 nCPM
fallopian tube ciliated cells: 310 nCPM
epididymal efferent duct ciliated cells: 255 nCPM

Immune cell

myeloid DC: 30 nTPM
intermediate monocyte: 22 nTPM
classical monocyte: 20 nTPM
non-classical monocyte: 9.5 nTPM
total PBMC: 8.2 nTPM
plasmacytoid DC: 4.1 nTPM

Brain region

choroid plexus: 70 nTPM
hypothalamus: 36 nTPM
midbrain: 32 nTPM
hippocampal formation: 31 nTPM
basal ganglia: 31 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein DPCD
DPCD protein family

InteractionsUniProt · HPA

Protein binding partners of DPCD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DPCD as an antibody target. Whether an autoantibody or antibody against DPCD could matter depends on whether native DPCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DPCD is annotated as secreted, so native DPCD circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label DPCD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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