Seroatlas · Human Serome Atlas

NOP58

Nucleolar protein 58

Also known as: HSPC120, NOP5, NOP58_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2X3
Gene: NOP58
Ensembl: ENSG00000055044
Chromosome: 2
Canonical length: 529 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

529 residues, UniProt reviewed canonical sequence.

>Q9Y2X3|NOP58
     1  MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF QDTAEALAAF
    61  TALMEGKINK QLKKVLKKIV KEAHEPLAVA DAKLGGVIKE KLNLSCIHSP VVNELMRGIR
   121  SQMDGLIPGV EPREMAAMCL GLAHSLSRYR LKFSADKVDT MIVQAISLLD DLDKELNNYI
   181  MRCREWYGWH FPELGKIISD NLTYCKCLQK VGDRKNYASA KLSELLPEEV EAEVKAAAEI
   241  SMGTEVSEED ICNILHLCTQ VIEISEYRTQ LYEYLQNRMM AIAPNVTVMV GELVGARLIA
   301  HAGSLLNLAK HAASTVQILG AEKALFRALK SRRDTPKYGL IYHASLVGQT SPKHKGKISR
   361  MLAAKTVLAI RYDAFGEDSS SAMGVENRAK LEARLRTLED RGIRKISGTG KALAKTEKYE
   421  HKSEVKTYDP SGDSTLPTCS KKRKIEQVDK EDEITEKKAK KAKIKVKVEE EEEEKVAEEE
   481  ETSVKKKKKR GKKKHIKEEP LSEEEPCTST AIASPEKKKK KKKKRENED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOP58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 72 nTPM
lymph node: 56 nTPM
tonsil: 56 nTPM
appendix: 41 nTPM
breast: 41 nTPM
skeletal muscle: 41 nTPM

Single-cell type

erythrocyte progenitors: 344 nCPM
pdcs: 299 nCPM
plasma cells: 283 nCPM
megakaryocyte-erythroid progenitors: 279 nCPM
t-cells: 266 nCPM
cone photoreceptor cells: 244 nCPM

Immune cell

naive CD8 T-cell: 59 nTPM
T-reg: 58 nTPM
naive CD4 T-cell: 58 nTPM
memory B-cell: 56 nTPM
MAIT T-cell: 55 nTPM
memory CD4 T-cell: 53 nTPM

Brain region

cerebellum: 32 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 27 nTPM
white matter: 25 nTPM
midbrain: 21 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0
gnomAD missense Z: 1.55
DepMap mean gene effect: -1.74
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOP58 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOP58 as an antibody target. Whether an autoantibody or antibody against NOP58 could matter depends on whether native NOP58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOP58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOP58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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