Seroatlas · Human Serome Atlas

ZNHIT1

Zinc finger HIT domain-containing protein 1

Also known as: CG1I, H_DJ0747G18.14, ZNFN4A1, ZNHI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43257
Gene: ZNHIT1
Ensembl: ENSG00000106400
Chromosome: 7
Canonical length: 154 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables histone binding activity. Involved in muscle cell differentiation and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>O43257|ZNHIT1
     1  MVEKKTSVRS QDPGQRRVLD RAARQRRINR QLEALENDNF QDDPHAGLPQ LGKRLPQFDD
    61  DADTGKKKKK TRGDHFKLRF RKNFQALLEE QNLSVAEGPN YLTACAGPPS RPQRPFCAVC
   121  GFPSPYTCVS CGARYCTVRC LGTHQETRCL KWTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNHIT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 337 nTPM

Expression across tissuesHPA

Tissue

liver: 337 nTPM
choroid plexus: 183 nTPM
kidney: 166 nTPM
spinal cord: 161 nTPM
midbrain: 149 nTPM
amygdala: 149 nTPM

Single-cell type

hepatocytes: 988 nCPM
esophageal apical cells: 426 nCPM
esophageal suprabasal cells: 393 nCPM
enterocytes: 368 nCPM
gastric progenitor cells: 346 nCPM
decidual stromal cells: 329 nCPM

Immune cell

total PBMC: 235 nTPM
basophil: 232 nTPM
eosinophil: 221 nTPM
classical monocyte: 215 nTPM
non-classical monocyte: 207 nTPM
intermediate monocyte: 203 nTPM

Brain region

white matter: 96 nTPM
cerebellum: 88 nTPM
medulla oblongata: 87 nTPM
choroid plexus: 82 nTPM
thalamus: 80 nTPM
spinal cord: 80 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNHIT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNHIT1 as an antibody target. Whether an autoantibody or antibody against ZNHIT1 could matter depends on whether native ZNHIT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNHIT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNHIT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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