Seroatlas · Human Serome Atlas

HTR6

5-hydroxytryptamine receptor 6

Also known as: 5-HT6, 5-HT6R, 5HT6R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50406
Gene
HTR6
Ensembl
ENSG00000158748
Chromosome
1
Canonical length
440 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>P50406|HTR6
     1  MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT
    61  SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI
   121  SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC
   181  RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP
   241  RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG
   301  LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP
   361  RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF
   421  FNIDPAEPEL RPHPLGIPTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
7 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 7 nTPM
  • cerebral cortex: 2.2 nTPM
  • hippocampal formation: 0.7 nTPM
  • hypothalamus: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • tonsil: 0.5 nTPM

Single-cell type

  • brain inhibitory neurons: 5.3 nCPM
  • epicardial cells: 2.3 nCPM
  • retinal amacrine cells: 1.8 nCPM
  • brain excitatory neurons: 1.4 nCPM
  • other brain neurons: 1.3 nCPM
  • differentiating spermatogonia: 1.2 nCPM

Immune cell

  • MAIT T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • basal ganglia: 22 nTPM
  • cerebral cortex: 6.2 nTPM
  • thalamus: 4.3 nTPM
  • hippocampal formation: 3.3 nTPM
  • white matter: 3.3 nTPM
  • amygdala: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HTR6.

Disease | ImmuneIEDB

Conditions an epitope on HTR6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HTR6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR6 as an antibody target. Whether an autoantibody or antibody against HTR6 could matter depends on whether native HTR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR6 is annotated at the cell surface, where native HTR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HTR6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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