Seroatlas · Human Serome Atlas

RPS6KB1

Ribosomal protein S6 kinase beta-1

Also known as: KS6B1_HUMAN, p70(S6K)-alpha, PS6K, S6K, S6K1, STK14A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P23443
Gene: RPS6KB1
Ensembl: ENSG00000108443
Chromosome: 17
Canonical length: 525 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

525 residues, UniProt reviewed canonical sequence.

>P23443|RPS6KB1
     1  MRRRRRRDGF YPAPDFRDRE AEDMAGVFDI DLDQPEDAGS EDELEEGGQL NESMDHGGVG
    61  PYELGMEHCE KFEISETSVN RGPEKIRPEC FELLRVLGKG GYGKVFQVRK VTGANTGKIF
   121  AMKVLKKAMI VRNAKDTAHT KAERNILEEV KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL
   181  FMQLEREGIF MEDTACFYLA EISMALGHLH QKGIIYRDLK PENIMLNHQG HVKLTDFGLC
   241  KESIHDGTVT HTFCGTIEYM APEILMRSGH NRAVDWWSLG ALMYDMLTGA PPFTGENRKK
   301  TIDKILKCKL NLPPYLTQEA RDLLKKLLKR NAASRLGAGP GDAGEVQAHP FFRHINWEEL
   361  LARKVEPPFK PLLQSEEDVS QFDSKFTRQT PVDSPDDSTL SESANQVFLG FTYVAPSVLE
   421  SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG
   481  IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH LRMNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 21 nTPM
bone marrow: 17 nTPM
tongue: 17 nTPM
pancreas: 16 nTPM
tonsil: 16 nTPM
esophagus: 15 nTPM

Single-cell type

myonuclei: 149 nCPM
epididymal basal cells: 95 nCPM
endometrial glandular cells: 83 nCPM
b-cells: 65 nCPM
distal convoluted tubule cells: 61 nCPM
urothelial cells: 58 nCPM

Immune cell

basophil: 44 nTPM
MAIT T-cell: 16 nTPM
myeloid DC: 15 nTPM
memory CD8 T-cell: 15 nTPM
non-classical monocyte: 14 nTPM
naive CD8 T-cell: 14 nTPM

Brain region

cerebellum: 33 nTPM
choroid plexus: 29 nTPM
white matter: 28 nTPM
cerebral cortex: 27 nTPM
pons: 26 nTPM
basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 3.9
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS6KB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS6KB1 as an antibody target. Whether an autoantibody or antibody against RPS6KB1 could matter depends on whether native RPS6KB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS6KB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS6KB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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