Seroatlas · Human Serome Atlas

PIH1D1

PIH1 domain-containing protein 1

Also known as: DNAAF14, FLJ20643, MOT48, NOP17, Pih1, PIHD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWS0
Gene
PIH1D1
Ensembl
ENSG00000104872
Chromosome
19
Canonical length
290 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables several functions, including enzyme binding activity; histone binding activity; and phosphoprotein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein-containing complex assembly. Located in cytoplasm and nucleolus. Part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and pre-snoRNP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q9NWS0|PIH1D1
     1  MANPKLLGMG LSEAEAIGAD SARFEELLLQ ASKELQQAQT TRPESTQIQP QPGFCIKTNS
    61  SEGKVFINIC HSPSIPPPAD VTEEELLQML EEDQAGFRIP MSLGEPHAEL DAKGQGCTAY
   121  DVAVNSDFYR RMQNSDFLRE LVITIAREGL EDKYNLQLNP EWRMMKNRPF MGSISQQNIR
   181  SEQRPRIQEL GDLYTPAPGR AESGPEKPHL NLWLEAPDLL LAEVDLPKLD GALGLSLEIG
   241  ENRLVMGGPQ QLYHLDAYIP LQINSHESKA AFHRKRKQLM VAMPLLPVPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIH1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
78 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 78 nTPM
  • skeletal muscle: 63 nTPM
  • tongue: 54 nTPM
  • kidney: 47 nTPM
  • parathyroid gland: 47 nTPM
  • salivary gland: 47 nTPM

Single-cell type

  • esophageal apical cells: 216 nCPM
  • extravillous trophoblasts: 146 nCPM
  • esophageal suprabasal cells: 142 nCPM
  • migrating cytotrophoblasts: 132 nCPM
  • cytotrophoblasts: 125 nCPM
  • esophageal basal cells: 125 nCPM

Immune cell

  • basophil: 168 nTPM
  • T-reg: 159 nTPM
  • eosinophil: 121 nTPM
  • memory B-cell: 117 nTPM
  • naive B-cell: 111 nTPM
  • non-classical monocyte: 109 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • thalamus: 30 nTPM
  • cerebral cortex: 29 nTPM
  • hippocampal formation: 28 nTPM
  • spinal cord: 27 nTPM
  • pons: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.64
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIH1D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIH1D1 as an antibody target. Whether an autoantibody or antibody against PIH1D1 could matter depends on whether native PIH1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIH1D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIH1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PIH1D1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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