Seroatlas · Human Serome Atlas

SLC38A7

Sodium-coupled neutral amino acid transporter 7

Also known as: FLJ10815, S38A7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVC3
Gene
SLC38A7
Ensembl
ENSG00000103042
Chromosome
16
Canonical length
462 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables L-asparagine:sodium symporter activity and L-glutamine:sodium symporter activity. Involved in asparagine transport and glutamine transport. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q9NVC3|SLC38A7
     1  MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT TSTLGAIFIV
    61  VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL VILAYCSQAS NERTYQEVVW
   121  AVCGKLTGVL CEVAIAVYTF GTCIAFLIII GDQQDKIIAV MAKEPEGASG PWYTDRKFTI
   181  SLTAFLFILP LSIPREIGFQ KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS
   241  WMAVFNAMPT ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL
   301  TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL WLRYQGVPVE
   361  EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG LAACFIFVFP GLCLIQAKLS
   421  EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ TTANAIFVDL LA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • heart muscle: 16 nTPM
  • liver: 14 nTPM
  • parathyroid gland: 13 nTPM
  • adrenal gland: 12 nTPM
  • spleen: 11 nTPM

Single-cell type

  • late spermatids: 1,387 nCPM
  • early spermatids: 393 nCPM
  • hofbauer cells: 78 nCPM
  • cardiomyocytes: 32 nCPM
  • adrenal cortex cells: 29 nCPM
  • choroid plexus epithelial cells: 27 nCPM

Immune cell

  • classical monocyte: 6.9 nTPM
  • intermediate monocyte: 6.6 nTPM
  • non-classical monocyte: 6.5 nTPM
  • total PBMC: 5.5 nTPM
  • myeloid DC: 4.5 nTPM
  • gdT-cell: 4 nTPM

Brain region

  • thalamus: 20 nTPM
  • cerebral cortex: 17 nTPM
  • pons: 16 nTPM
  • midbrain: 15 nTPM
  • basal ganglia: 14 nTPM
  • hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
1
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC38A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A7 as an antibody target. Whether an autoantibody or antibody against SLC38A7 could matter depends on whether native SLC38A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC38A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC38A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...